Christoph P Bagowski

US Patent:

20070099199, May 3, 2007

Filed:

Apr 11, 2006

Appl. No.:

11/403141

Inventors:

Peter Lu - Mountain View CA, US
Christoph Bagowski - Palo Alto CA, US
Johannes Schweizer - Mountain View CA, US
Chamorro Diaz-Sarmiento - Palo Alto CA, US
Jonathan Garman - San Jose CA, US
Michael Belmares - San Jose CA, US

International Classification:

C12Q 1/68
C12N 5/06
C12N 5/16

US Classification:

435006000, 435345000

Abstract:

The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid sequence of a particular PDZ domain from the cellular protein MAGI-1. The invention provides methods to treat diseases associated with expression of pathogen proteins by modulating their interactions with MAGI-1, and a number of isolated peptides useful in such methods. Also provided are kits for performing the subject methods.

US Patent:

20100120700, May 13, 2010

Filed:

Oct 27, 2009

Appl. No.:

12/606905

Inventors:

Peter S. Lu - Palo Alto CA, US
Christoph Peter Bagowski - Palo Alto CA, US
Johannes Schweizer - Mountain View CA, US
Chamorro Somoza Diaz-Sarmiento - Palo Alto CA, US
Jonathan David Garman - San Jose CA, US
Michael P. Belmares - San Jose CA, US

Assignee:

Arbor Vita Corporation - Sunnyvale CA

International Classification:

A61K 38/05
C12Q 1/70
C07K 2/00
C12N 5/00

US Classification:

514 19, 435 5, 530300, 435375

Abstract:

The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid sequence of a particular PDZ domain from the cellular protein MAGI-1. The invention provides methods to treat diseases associated with expression of pathogen proteins by modulating their interactions with MAGI-1, and a number of isolated peptides useful in such methods. Also provided are kits for performing the subject methods.

US Patent:

20040229298, Nov 18, 2004

Filed:

Feb 27, 2004

Appl. No.:

10/789102

Inventors:

Peter Lu - Mountain View CA, US
Christoph Bagowski - Palo Alto CA, US
Johannes Schweizer - Mountain View CA, US
Chamorro Diaz-Sarmiento - Palo Alto CA, US
Jonathan Garman - San Jose CA, US
Michael Belmares - San Jose CA, US

International Classification:

C12Q001/68
G01N033/574
C07K014/705

US Classification:

435/007230, 530/350000

Abstract:

The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid sequence of a particular PDZ domain from the cellular protein MAGI-1. The invention provides methods to treat diseases associated with expression of pathogen proteins by modulating their interactions with MAGI-1, and a number of isolated peptides useful in such methods. Also provided are kits for performing the subject methods.