Christopher F Armstrong

US Patent:

7452664, Nov 18, 2008

Filed:

Dec 15, 1999

Appl. No.:

09/461580

Inventors:

Leonard Guarente - Chestnut Hill MA, US
Shin-ichiro Imai - Somerville MA, US
Christopher Armstrong - Cambridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 6, 435 4, 435 5, 435 76, 435 15

Abstract:

Methods of identifying agents which alter the NAD-dependent acetylation status and mono-ADP-ribosylation of nuclear proteins are disclosed. The methods further include identifying agents which alter the life span or aging of a cell or an organism by determining the level of NAD-dependent acetylation and/or ADP ribosylation of a nuclear protein. The invention also relates to a mammalian Sir2 protein which acetylates or deacetylates nuclear proteins in a NAD-dependent manner and has mono-ADP-ribosyltransferase activity. Host cells producing the Sir2 protein and antibodies to the Sir2 protein are also provided.

US Patent:

8642284, Feb 4, 2014

Filed:

Dec 13, 2000

Appl. No.:

09/735786

Inventors:

Leonard Guarente - Chestnut Hill MA, US
Shin-Ichiro Imai - St. Louis MO, US
Christopher Armstrong - Jamaica Plain MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C12Q 1/02
C12N 9/00

US Classification:

435 29, 435183

Abstract:

Methods of identifying agents which alter the NAD-dependent deacetylation activity of a Sir2 protein or a fragment of a Sir2 protein are disclosed. The acetylated protein can be a nuclear protein, such as a histone protein, or a cytoplasmic protein. The Sir2 protein employed in the methods can include at least a core domain of a Sir2 protein, such as a human Sir2 protein.

US Patent:

20090155834, Jun 18, 2009

Filed:

Sep 12, 2008

Appl. No.:

12/209847

Inventors:

LEONARD GUARENTE - CHESTNUT HILL MA, US
SHIN-ICHIRO IMAI - SOMERVILLE MA, US
CHRISTOPHER ARMSTRONG - CAMBRIDGE MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - CAMBRIDGE MA

International Classification:

C12Q 1/02
C12N 9/00

US Classification:

435 29, 435183

Abstract:

Methods of identifying agents which alter the NAD-dependent acetylation status and mono-ADP-ribosylation of nuclear proteins are disclosed. The methods further include identifying agents which alter the life span or aging of a cell or an organism by determining the level of NAD-dependent acetylation and/or ADP ribosylation of a nuclear protein. The invention also relates to a mammalian Sir2 protein which acetylates or deacetylates nuclear proteins in a NAD-dependent manner and has mono-ADP-ribosyltransferase activity. Host cells producing the Sir2 protein and antibodies to the Sir2 protein are also provided.

US Patent:

20200113591, Apr 16, 2020

Filed:

Sep 19, 2019

Appl. No.:

16/576287

Inventors:

Christopher Armstrong - Apopka FL, US

International Classification:

A61B 17/29

Abstract:

A surgical instrument system includes a main body having a handle and a drive assembly. The drive assembly includes a plurality of gears and rotation transfer mechanisms for translating the movements of the handle into a mechanical force. A surgical tool having a tool body, an elongated shaft and an effector assembly is removably engaged to the main body of the system. The tool body houses a transfer gear assembly for engaging the drive assembly. A plurality of control wires extends from the transfer gear assembly to the effector assembly. The effector assembly includes a frame member having a pair of arms positioned along the distal end. The arms functioning to selectively open, close and move omnidirectionally based on an input of the handle.