Christopher J Austin

US Patent:

20130123214, May 16, 2013

Filed:

Jul 19, 2011

Appl. No.:

13/810774

Inventors:

Wei Zheng - Potomac MD, US
Juan Jose Marugan - Gaithersburg MD, US
Ke Liu - Cambridge MD, US
Noel Terrence Southall - Chevy Chase MD, US
Christopher P. Austin - Potomac MD, US

Assignee:

The United States of America as Represented by the Secretary Department of HR - Rockville MD

International Classification:

A61K 31/355
A61K 31/724
A61K 45/06

US Classification:

514 58, 514458

Abstract:

This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of delta tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol in combination with cyclodextrin to a patient in need thereof.

US Patent:

20170027903, Feb 2, 2017

Filed:

Aug 17, 2016

Appl. No.:

15/239753

Inventors:

- Rockville MD, US
Juan Jose Marugan - Gaithersburg MD, US
Ke Liu - Cambridge MD, US
Noel Terrence Southall - Chevy Chase MD, US
Christopher P. Austin - Potomac MD, US

International Classification:

A61K 31/355
A61K 31/36
A61K 36/185
A61K 31/496
A61K 31/724
A61K 45/06

Abstract:

This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of δ tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of δ tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of δ tocopherol in combination with cyclodextrin to a patient in need thereof.

US Patent:

20150265571, Sep 24, 2015

Filed:

May 13, 2015

Appl. No.:

14/711381

Inventors:

- ROCKVILLE MD, US
Juan Jose MARUGAN - GAITHERSBURG MD, US
Ke LIU - CAMBRIDGE MD, US
Noel Terrence SOUTHALL - CHEVY CHASE MD, US
Christopher P. AUSTIN - POTOMAC MD, US

International Classification:

A61K 31/355

Abstract:

This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of δ tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of δ tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of δ tocopherol in combination with cyclodextrin to a patient in need thereof.

US Patent:

20140148398, May 29, 2014

Filed:

Oct 12, 2011

Appl. No.:

13/878832

Inventors:

Wei Zheng - Potomac MD, US
Catherine Chen - Germantown MD, US
Juan Jose Marugan - Gaithersburg MD, US
Noel Southall - Potomac MD, US
Christopher P. Austin - Potomac MD, US
Andrey Galkin - Germantown MD, US
Liudmila Kulakova - Germantown MD, US
Osnat Herzberg - Rockville MD, US

Assignee:

The United States of America, as represented by the Secretary, Dept. of Health and Human Service - Bethesda MD
UNIVERSITY OF MARYLAND, COLLEGE PARK - College Park MD

International Classification:

A61K 31/7135
A61K 31/706
A61K 31/525
A61K 31/05
A61K 31/4375
A61K 31/345
A61K 31/426
A61K 31/428
A61K 31/336
A61K 31/498

US Classification:

514 24, 514475, 514 64, 514378, 514504, 514 43, 514251, 514367, 514249, 514619, 514 52, 514 36, 514280, 514291, 514483, 514281, 514 34, 514653, 514250, 514183, 514395, 514753, 514733, 514371, 514472

Abstract:

Compounds useful for the treatment of giardiasis are described.