Christopher M Bowman

US Patent:

7288608, Oct 30, 2007

Filed:

Oct 10, 2002

Appl. No.:

10/269916

Inventors:

Christopher Bowman - Boulder CO, US
Kristi Anseth - Boulder CO, US
Bilge Hacioglu - Boulder CO, US
Charlie Nuttelman - Boulder CO, US

Assignee:

Regents of the University of Colorado - Boulder CO

International Classification:

C08G 81/00

US Classification:

525535, 525 58, 525 60, 525417, 525420, 525426, 525433, 525434, 525450, 525461, 525467, 525468, 5361231

Abstract:

A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.

US Patent:

7354706, Apr 8, 2008

Filed:

Mar 9, 2006

Appl. No.:

11/372485

Inventors:

Kathy L. Rowlen - Longmont CO, US
John W. Birks - Longmont CO, US
Christopher Bowman - Boulder CO, US
Hadley Sikes - Westminster CO, US
Ryan Hansen - Boulder CO, US
Robert Kuchta - Boulder CO, US

Assignee:

The Regents of The University of Colorado, a body corporate - Boulder CO

International Classification:

C12Q 1/68
C12Q 1/70
G01N 33/53

US Classification:

435 5, 4242061, 4242091, 435 6, 435 71, 536 231

Abstract:

The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular recognition event. The amplification is achieved through photopolymerization, with the polymer formed being associated with the molecular recognition event. In an embodiment, a fluorescent polymer, a magnetic polymer, a radioactive polymer or an electrically conducting polymer can form the basis of detection and amplification. In another embodiment, a polymer gel swollen with a fluorescent solution, a magnetic solution, a radioactive solution or an electrically conducting solution can form the basis of detection and amplification. In another embodiment, sufficient polymer forms to be detectable by visual inspection.

US Patent:

7498394, Mar 3, 2009

Filed:

Feb 20, 2004

Appl. No.:

10/547220

Inventors:

Christopher N. Bowman - Boulder CO, US
Jeffrey W. Stansbury - Centennial CO, US
Kathryn A. Berchtold - Los Alamos NM, US
Jun Nie - Boulder CO, US

Assignee:

The Regents of the University of Colorado - Boulder CO

International Classification:

C08F 226/02
C08F 20/00
C07C 271/00

US Classification:

526301, 526302, 560157, 560158, 560163

Abstract:

The present invention provides novel (meth)acrylic and (meth)acrylamide monomers and polymers produced from those monomers. The monomers of the invention each include only a single vinyl functionality and at least one non-vinyl functionality that can be varied to achieve desired monomer/polymer properties. The invention additionally provides methods of producing polymers from these mono-vinyl monomers.

US Patent:

7838571, Nov 23, 2010

Filed:

Oct 22, 2004

Appl. No.:

10/576635

Inventors:

Christopher N. Bowman - Boulder CO, US
Hui Lu - Dover DE, US
Jeffrey W. Stansbury - Centennial CO, US

Assignee:

The Regents of the University of Colorado - Denver CO

International Classification:

A61K 6/087
A61K 6/08
C08G 75/00

US Classification:

522 44, 522 48, 522167, 522180, 523115, 523116

Abstract:

Photopolymerizable polymer composites based on dimethacrylate systems have been increasingly utilized as dental restorative materials. One of the biggest drawbacks of current dental resin systems is the volume shrinkage and shrinkage induced stresses that arise during the polymerization. Other major problems include incomplete double bond conversion and insufficient wear resistance. This invention involves the development of an entirely novel approach to the photopolymerization process that utilizes thiol-ene systems as low shrinkage and ultra-low shrinkage stress dental restorative materials. Compared with the traditional dimethacrylate dental resins, these novel photopolymerizations have demonstrated a dramatically decreased volume shrinkage, extremely rapid polymerization, abilities to photopolymerize ultrathick materials and achieve much higher conversion, lack of oxygen inhibition and ultra-low shrinkage stress due to low volume shrinkage and drastically delayed gel point conversion. These polymers have thus shown outstanding suitability as dental restorative materials.

US Patent:

7943680, May 17, 2011

Filed:

Feb 10, 2006

Appl. No.:

11/815914

Inventors:

Christopher N. Bowman - Boulder CO, US
Timothy F. Scott - Boulder CO, US

Assignee:

The Regents of the University of Colorado - Denver CO

International Classification:

C08F 2/50
C08J 3/28

US Classification:

522 6, 522 7, 522 1, 522 31, 522 35, 522 49, 522106, 522107, 522173, 522150, 522153, 522162, 522178, 522189, 522181, 522904, 523300

Abstract:

The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention.

US Patent:

8306931, Nov 6, 2012

Filed:

Aug 6, 2009

Appl. No.:

12/462634

Inventors:

Christopher Bowman - Broomfield CO, US
Duane DeSieno - LaJolla CA, US

Assignee:

Data Fusion & Neural Networks, LLC - Broomfield CO

International Classification:

G06E 1/00
G06E 3/00
G06F 15/18
G06G 7/00
G06N 3/04

US Classification:

706 27, 706 20, 706 26

Abstract:

The present invention extends to methods, systems, and computer program products for detecting, classifying, and tracking abnormal data in a data stream. Embodiments include an integrated set of algorithms that enable an analyst to detect, characterize, and track abnormalities in real-time data streams based upon historical data labeled as predominantly normal or abnormal. Embodiments of the invention can detect, identify relevant historical contextual similarity, and fuse unexpected and unknown abnormal signatures with other possibly related sensor and source information. The number, size, and connections of the neural networks all automatically adapted to the data. Further, adaption appropriately and automatically integrates unknown and known abnormal signature training within one neural network architecture solution automatically. Algorithms and neural networks architecture are data driven, resulting more affordable processing. Expert knowledge can be incorporated to enhance the process, but sufficient performance is achievable without any system domain or neural networks expertise.

US Patent:

8404758, Mar 26, 2013

Filed:

May 17, 2011

Appl. No.:

13/109400

Inventors:

Christopher N. Bowman - Boulder CO, US
Timothy F. Scott - Boulder CO, US

Assignee:

The Regents of the University of Colorado, a body corporate - Denver CO

International Classification:

C08F 2/50
C07C 323/00
C07C 323/05

US Classification:

522180, 522 7, 522 6, 522 31, 522 35, 522 49, 522107, 522104, 522173, 522150, 522153, 522170, 522162, 522178, 522189, 522181, 522904, 523300, 523109, 523113, 523114, 523115, 523116, 523118, 523120, 568 11, 568 13, 568 18, 568 22, 568 29, 568 31, 568 32, 568 38, 568 39

Abstract:

The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention.

US Patent:

8431626, Apr 30, 2013

Filed:

May 18, 2011

Appl. No.:

13/110898

Inventors:

Christopher N. Bowman - Boulder CO, US
Hee Young Park - Asan-si, KR
Christopher J. Kloxin - Newark DE, US
Ahmed S. Abuelyaman - Woodbury MN, US
Joel D. Oxman - Minneapolis MN, US
Yizhong Wang - Woodbury MN, US

Assignee:

3M Innovative Properties Company - St. Paul MN
The Regents of the University of Colorado - Denver CO

International Classification:

A61K 6/083
C07C 321/20
C07C 321/16
C08F 232/06
C08F 236/20

US Classification:

523115, 568 38, 568 57, 568 58, 4332281, 106 35, 526281, 526282

Abstract:

Dental compositions and disulfide monomers described. The disulfide monomer comprises a disulfide backbone group wherein each of the sulfur atoms are bonded to a group terminating with an ethylenically unsaturated norbornyl group; and at least one other monomer comprising at least two ethylenically unsaturated groups.