Christopher M Burns

Address:

808 Patton Chapel Trl, Hoover, AL 35226

VIN:

4T1BF3EK8AU114532

Make:

TOYOTA

Model:

CAMRY

Year:

2010

US Patent:

6541505, Apr 1, 2003

Filed:

Jun 30, 2000

Appl. No.:

09/609103

Inventors:

William P. Dankulich - Collegeville PA
Daniel G. McGarry - Bedminster NJ
Christopher Burns - Malvern PA
Timothy F. Gallagher - Harleysville PA
Francis A. Volz - Philadelphia PA

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

A61K 31405

US Classification:

514415, 514428, 514275, 514396, 514397, 5142358, 514354, 544322, 544238, 544335, 544330, 544162, 544405, 5483111, 5483351, 5483355, 548505, 548504, 546314, 546329, 546340, 5462774

Abstract:

This invention is directed to an (aminoiminomethyl or aminomethyl)benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.

US Patent:

6599918, Jul 29, 2003

Filed:

Feb 22, 2002

Appl. No.:

10/081113

Inventors:

Christopher J. Burns - Malvern PA
William P. Dankulich - Collegeville PA
Daniel G. McGarry - Bedminister NJ
Francis A. Volz - Neshanic Station NJ

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

A61K 31443

US Classification:

514314, 514337, 514407, 514414, 5483644, 548454, 546122, 5462841, 549 58, 549467

Abstract:

This invention is directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans that inhibit Factor Xa, pharmaceutical compositions comprising these compounds and their use for inhibiting Factor Xa or treating pathological conditions in a patient that may be ameliorated by administration of such compounds. This invention is also is also directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans which directly inhibit both Factor Xa and Factor IIa (thrombin), to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of simultaneously directly inhibiting both Factor Xa and Factor IIa (thrombin).

US Patent:

7265152, Sep 4, 2007

Filed:

Oct 31, 2003

Appl. No.:

10/699336

Inventors:

Ashis K. Saha - Harleysville PA, US
Christopher J Burns - Malvern PA, US
Alfred M. Del Vecchio - West Chester PA, US
Thomas R. Bailey - Phoenixville PA, US
Jason A. Reinhardt - Audubon PA, US
Bheemashankar A. Kulkarni - Exton PA, US
Thomas H. Faitg - Exton PA, US
Hao Feng - Aston PA, US
Susan R. Rippin - Wilmington DE, US
Charles W. Blackledge - Spring City PA, US
David J. Rys - Philadelphia PA, US
Thomas A. Lessen - Langhorne PA, US
John Swestock - Reading PA, US
Yijun Deng - Dresher PA, US
Theodore J. Nitz - Pottstown PA, US

Assignee:

ViroPharma Incorporated - Exton PA
Wyeth - Madison NJ

International Classification:

A61K 31/343
C07D 307/87

US Classification:

514469, 549468, 549469

Abstract:

The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.

US Patent:

7666863, Feb 23, 2010

Filed:

May 24, 2007

Appl. No.:

11/753145

Inventors:

Ashis K. Saha - Harleysville PA, US
Christopher J Burns - Malvern PA, US
Alfred M. Del Vecchio - West Chester PA, US
Thomas R. Bailey - Phoenixville PA, US
Jason A. Reinhardt - Audubon PA, US
Bheemashankar A. Kulkarni - Exton PA, US
Thomas H. Faitg - Exton PA, US
Hao Feng - Aston PA, US
Susan R. Rippin - Wilmington DE, US
Charles W. Blackledge - Spring City PA, US
David J. Rys - Philadelphia PA, US
Thomas A. Lessen - Langhorne PA, US
John Swestock - Reading PA, US
Yijun Deng - Dresher PA, US
Theodore J. Nitz - Pottstown PA, US

Assignee:

ViroPharma Incorporated - Exton PA
WYETH - Madison NJ

International Classification:

A61K 31/54
A61K 31/53
C07D 307/00
C07D 401/00
C07D 417/00

US Classification:

5142222, 5142265, 5142288, 514241, 51425201, 514279, 514337, 514359, 514365, 514383, 514408, 514444, 514468, 514469, 549469, 548146, 548215, 548256, 5483111, 544 60, 544 66, 544111, 544152, 544153, 544179

Abstract:

The present invention relates to benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.

US Patent:

8119672, Feb 21, 2012

Filed:

Aug 11, 2003

Appl. No.:

10/524313

Inventors:

David J. Rys - Phialdelphia PA, US
Theodore J. Nitz - Pottstown PA, US
Janet A Gaboury - Blue Bell PA, US
Christopher J. Burns - Malvern PA, US
Daniel C. Pevear - Harleysville PA, US
Thomas A. Lessen - Langhorne PA, US
Torsten Herbertz - Honey Brook PA, US

Assignee:

Microdose Therapeutx, Inc. - Monmouth Junction NJ

International Classification:

A61K 31/41
C07D 43/02

US Classification:

514381, 548282

Abstract:

Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.

US Patent:

8202896, Jun 19, 2012

Filed:

Aug 11, 2003

Appl. No.:

10/524162

Inventors:

Theodore J. Nitz - Pottstown PA, US
Janet A. Gaboury - Blue Bell PA, US
Christopher J. Burns - Malvern PA, US
Sylvie Laguerre - Exton PA, US
Daniel C. Pevear - Harleysville PA, US
Thomas A. Lessen - Langhorne PA, US
David J. Rys - Philadelphia PA, US

Assignee:

Microdose Therapeutx, Inc. - Monmouth Junction NJ

International Classification:

A61K 31/41
C07D 257/06

US Classification:

514381, 548251

Abstract:

Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.

US Patent:

8575205, Nov 5, 2013

Filed:

Mar 22, 2012

Appl. No.:

13/427664

Inventors:

Theodore J. Nitz - Pottstown PA, US
Janet A. Gaboury - Blue Bell PA, US
Christopher J. Burns - Malvern PA, US
Sylvie Laguerre - Exton PA, US
Daniel C. Pevear - Harleysville PA, US
Thomas A. Lessen - Langhorne PA, US
David J. Rys - Philadelphia PA, US

Assignee:

Microdose Therapeutx, Inc. - Monmouth Junction NJ

International Classification:

A61K 31/41
C07D 257/06

US Classification:

514381, 548251

Abstract:

Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.

US Patent:

20030153604, Aug 14, 2003

Filed:

Feb 24, 2003

Appl. No.:

10/372499

Inventors:

William Dankulich - Collegeville PA, US
Daniel McGarry - Bedminster NJ, US
Christopher Burns - Malvern PA, US
Timothy Gallagher - Harleysville PA, US
Francis Volz - Neshanic Station NJ, US

Assignee:

Aventis Pharmaceuticals Inc. - Bridgewater NJ

International Classification:

C07D409/02
C 07D 4 5/02
C07D333/72
A61K031/4439
A61K031/405
A61K031/4025
A61K031/381
A61K031/343

US Classification:

514/337000, 514/418000, 514/419000, 514/422000, 514/443000, 514/469000, 546/277400, 546/281100, 546/284100, 548/465000, 548/503000, 549/055000, 549/467000

Abstract:

This invention is directed to an (aminoiminomethyl or aminomethyl)benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.