Christopher C. Caires - Menlo Park CA, US Samira Guccione - Hillsborough CA, US
Assignee:
The Board Of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C07C 25/13 B32B 15/00
US Classification:
570147, 428696
Abstract:
The methods of the disclosure may be used for the fluorination of organic compounds, and in particular aryl organic compounds other than just benzyl halogens. It is within the scope of the present disclosure, for organic compounds comprising an electrophilic carbon atom and a halogen leaving group to be fluorinated by the methods of the disclosure. One aspect of the disclosure provides methods of introducing a fluorine atom onto an electrophilic carbon atom, comprising mixing an insoluble basic silver salt, an organic molecule containing a leaving group, an aqueous solution of hydrofluoric acid, and a polar solvent:water composition; incubating said mixture at a temperature of about 20 C. to about 35 C., thereby obtaining a fluorinated organic product.
Methods For Silver Promoted Fluorination Of Organic Molecules
Christopher C. Caires - Menlo Park CA, US Samira Guccione - Hillsborough CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
B01J 27/12 B01J 27/232
US Classification:
502174, 502224
Abstract:
The methods of the disclosure may be used for the fluorination of organic compounds, and in particular aryl organic compounds other than just benzyl halogens. It is within the scope of the present disclosure, for organic compounds comprising an electrophilic carbon atom and a halogen leaving group to be fluorinated by the methods of the disclosure. One aspect of the disclosure provides methods of introducing a fluorine atom onto an electrophilic carbon atom, comprising mixing an insoluble basic silver salt, an organic molecule containing a leaving group, an aqueous solution of hydrofluoric acid, and a polar solvent:water composition; incubating said mixture at a temperature of about 20 C. to about 35 C., thereby obtaining a fluorinated organic product.
Systems And Methods For Treating And/Or Preventing Acne
The present invention generally relates to skin care and, in particular, to systems and methods for treating and/or preventing acne. Acne is believed to be caused by a combination of factors, including bacteria, excess sebum production, and inflammation from the immune response (e.g., in response to ). Certain aspects of the invention are thus directed to one or more compositions that collectively target these factors, although it should be understood that a single composition may target more than one factor at a time. For instance, in one set of embodiments, a treatment may include a first composition that cleans the skin, a second composition that contains growth inhibitor of (e.g., for use during the day), and a third composition that inhibits sebum production (e.g., for use during the night). One or more of these may contain other components, such as anti-inflammatory agents, moisturizers, topical anti-microbial agents (e.g., salicylic acid), or the like. Other aspects are generally directed to methods of making or use of such compositions, kits including such compositions, or the like.
Systems And Methods For Treating And/Or Preventing Acne
The present invention generally relates to skin care and, in particular, to systems and methods for treating and/or preventing acne. Acne is believed to be caused by a combination of factors, including bacteria, excess sebum production, and inflammation from the immune response (e.g., in response to ). Certain aspects of the invention are thus directed to one or more compositions that collectively target these factors, although it should be understood that a single composition may target more than one factor at a time. For instance, in one set of embodiments, a treatment may include a first composition that cleans the skin, a second composition that contains growth inhibitor of (e.g., for use during the day), and a third composition that inhibits sebum production (e.g., for use during the night). One or more of these may contain other components, such as anti-inflammatory agents, moisturizers, topical anti-microbial agents (e.g., salicylic acid), or the like. Other aspects are generally directed to methods of making or use of such compositions, kits including such compositions, or the like.
A method for improving the appearance of the skin, moisturizing skin and/or providing an antioxidant effect to skin by administering to skin a composition comprising an effective amount of a hydrogen-generating agent or molecular hydrogen and a carrier having a phosphatidylcholine component entrapping the hydrogen-generating agent or molecular hydrogen. A skin care product has an effective amount of molecular hydrogen and/or a hydrogen-generating agent; and a carrier entrapping them. Desirably, the composition is an aqueous base, and the hydrogen-generating agent and the carrier form a first phase of the composition, and an emulsifier forms a second phase of the composition.
An encapsulated cleaning composition includes a core cleaning composition and a water-soluble film disposed about the core cleaning composition. The core cleaning composition itself includes an ionic liquid, water present in an amount of from 10 to 50 parts by weight per 100 parts by weight of the core cleaning composition, and at least one of a chelant, an enzyme, and a surfactant. The water-soluble film has a disintegration time of less than 90 seconds as determined at 40 C. using distilled water according to MSTM 205, when disposed about the core cleaning composition. The water-soluble film also remains stable for 6 months at 25 C., when disposed about the core cleaning composition.