Christopher N Casciano

US Patent:

6703400, Mar 9, 2004

Filed:

Mar 22, 2002

Appl. No.:

10/104554

Inventors:

William W. Johnson - Sparta NJ
Christopher Casciano - Newton NJ
Robert P. Clement - Morris Plains NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 3144

US Classification:

514290, 514 34, 514 90, 514922

Abstract:

Methods are provided for treating multidrug resistance in refractory tumor cells comprising administering (1) a P-glycoprotein inhibitor in conjunction with (2) an antineoplastic agent.

US Patent:

20040176403, Sep 9, 2004

Filed:

Mar 3, 2004

Appl. No.:

10/791922

Inventors:

William Johnson - Sparta NJ, US
Christopher Casciano - Newton NJ, US
Roger Clement - Morris Plains NJ, US

International Classification:

A61K031/473

US Classification:

514/290000

Abstract:

Methods are provided for treating multidrug resistance in refractory tumor cells comprising administering (1) a P-glycoprotein inhibitor in conjunction with (2) an antineoplastic agent.

US Patent:

6599913, Jul 29, 2003

Filed:

Jun 21, 2002

Appl. No.:

10/177271

Inventors:

William W. Johnson - Sparta NJ
Christopher Casciano - Newton NJ
Robert P. Clement - Morris Plains NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31473

US Classification:

514290

Abstract:

A method of treating and/or preventing allergic and inflammatory conditions of the skin or airway passages in a human in need of such treating and/or preventing which comprises administering to said human an effective amount of a nonsedating antihistamine for such treating and/or preventing while avoiding the side effects associated with other nonsedating antihistamines that bind to the P-glycoprotein pump and/or the organic anion transport polypeptide pump is disclosed.