Christopher D Chen

US Patent:

7132275, Nov 7, 2006

Filed:

May 14, 2002

Appl. No.:

10/143813

Inventors:

Daniel Reich - Baltimore MD, US
Gerald Meyer - Baltimore MD, US
Chia-Ling Chien - Lutherville MD, US
Christopher Chen - Baltimore MD, US
Peter C. Searson - Balto MD, US

Assignee:

The John Hopkins University - Baltimore MD

International Classification:

C07H 21/04
C12Q 1/68

US Classification:

4352871, 536 231, 536 243, 977704, 977728, 977769

Abstract:

The invention provides multisegmented, multifunctional magnetic nanowires for the probing and manipulation of molecules at the cellular and subcellular level. The different segments of the nanowire may have differing properties, including a variety of magnetic, non-magnetic, and luminescent behavior. Differences in surface chemistry allow different segments of a single nanowire to be functionalized with different multiple functional groups and/or ligands, giving the wire chemical multifunctionality.

US Patent:

7288394, Oct 30, 2007

Filed:

Sep 23, 2003

Appl. No.:

10/668679

Inventors:

Emanuele Ostuni - Watertown MA, US
Christopher S. Chen - Baltimore MD, US
Donald E. Ingber - Boston MA, US
George M. Whitesides - Newton MA, US

Assignee:

President & Fellows of Harvard College - Cambridge MA
Children's Medical Center Corporation - Boston MA

International Classification:

C12N 11/02
C12N 11/08
C07K 17/02
C07K 17/08

US Classification:

435177, 435180, 530812, 530815

Abstract:

A method of patterning materials, such as proteins, on a contoured surface by depositing them onto protrusions on a surface, and a cell containment device that may be constructed by this method, are provided. The method may involve selectively depositing a material on a substrate including a contoured surface including protrusions and recesses. By applying a first fluid to the contoured surface and allowing the first fluid to distribute across only a portion of the contoured surface, a material may be deposited on the protrusions and not the recesses, or on the recesses and not the protrusions. Such a method may be used to selectively pattern cells or other materials on substrates.

US Patent:

20020182633, Dec 5, 2002

Filed:

Jul 11, 2001

Appl. No.:

09/904200

Inventors:

Christopher Chen - Baltimore MD, US
Joe Tien - Brookline MA, US
John Tan - Baltimore MD, US
Sangeeta Bhatia - La Jolla CA, US
William Jastromb - Baltimore MD, US

International Classification:

B05D003/00
C12Q001/68
G01N033/53

US Classification:

435/007100, 427/002110, 435/006000

Abstract:

The invention relates to a method of adhering a biomolecule to a substrate, comprising treating the substrate with a surfactant compound and a biomolecule. More particularly, the invention relates to a method of adhering a biomolecule to a substrate wherein the surfactant compound is not covalently linked to the substrate. The invention also relates to a device for adhering a biomolecule in a predetermined position comprising: a substrate having thereon a plurality of cytophilic regions that can adhere a biomolecule on the substrate by cytophobic regions to which the biomolecules do not adhere contiguous with the cytophilic regions, wherein the cytophobic regions comprise one or more surfactant compounds.

US Patent:

20050152338, Jul 14, 2005

Filed:

Jan 14, 2004

Appl. No.:

10/758350

Inventors:

Christopher Chen - San Francisco CA, US
Victor Zhao - San Francisco CA, US

International Classification:

H04L012/66

US Classification:

370352000

Abstract:

A system and method for managing voice communications routes a first telephone call from a remote source to a remote destination using a second telephone call. The first telephone call is made through a first network, which may be one of a circuit switching network and a packet switching network, while the second telephone call is made through a second network, which is one of the circuit and packet switching network that differs from the first network. The second telephone call is initiated in response to the first telephone call. The first and second telephone calls are then interconnected to connect the remote source to the remote destination.

US Patent:

20050152347, Jul 14, 2005

Filed:

Jan 14, 2004

Appl. No.:

10/757904

Inventors:

Christopher Chen - San Francisco CA, US
Victor Zhuo - San Francisco CA, US

International Classification:

H04L012/66

US Classification:

370356000, 370401000

Abstract:

A system and method for managing voice communications utilizes a switching unit to selectively interconnect signal paths between a telephone, a circuit switching network and a packet switching network at the premises of a telephone line subscriber to selectively route telecommunication signals between the telephone, the circuit switching network and the packet switching network. Thus, the switching unit allows one or more telephone calls to be established through the circuit switching network and/or through the packet switching network.

US Patent:

20050260975, Nov 24, 2005

Filed:

May 19, 2004

Appl. No.:

10/848954

Inventors:

Christopher Chen - San Francisco CA, US
Victor Zhuo - San Francisco CA, US

International Classification:

H04B001/38
H04M001/00

US Classification:

455415000, 455567000, 455426100

Abstract:

A telecommunications system and method for providing a notification of the availability of a target communication device to receive a call monitors the target communication device to effectuate a generation of a notification signal at a calling communication device when the target communication device is available to receive a call. The monitoring of the target communication device may involve receiving the latest status information of the target communication device from a network, such as a Voice over Internet Protocol (VoIP) network or a cellular telephone network.

US Patent:

20080145908, Jun 19, 2008

Filed:

Sep 14, 2007

Appl. No.:

11/901277

Inventors:

Emanuele Ostuni - Watertown MA, US
Christopher S. Chen - Baltimore MD, US
Donald E. Ingber - Boston MA, US
George M. Whitesides - Newton MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12N 11/08

US Classification:

435180

Abstract:

The present invention is directed to a method of patterning materials, such as proteins, on a contoured surface by depositing them onto protrusions on the surface and to a cell containment device that may be constructed by this method. In one embodiment, the present invention is directed to a method of selectively depositing a material on a substrate including a contoured surface including a protrusion and a recess. The method includes applying a first fluid to the contoured surface of the substrate and allowing the first fluid to distribute across a portion of the contoured surface such that the first fluid contacts the protrusion and not the recess. The method also includes allowing a first material to deposit on the substrate where the substrate is in contact with the first fluid. Optionally, this method may further include applying a second fluid to the contoured surface of the substrate, allowing the second fluid to distribute across a portion of the contoured surface such that the second fluid contacts the recess, and allowing a second material to deposit on the substrate where the substrate is in contact with the second fluid. Optionally, the method may still further include applying a third fluid to the contoured surface of the substrate, allowing the third fluid to distribute across a portion of the contoured surface, and allowing a third material with an affinity for one of the first material and the second material to deposit on the substrate only where the one of the first material and the second material is deposited. In one embodiment of this method the first material is a cytophobic material, the second material is a cytophilic material and the third material is a cell.In another embodiment, the present invention is directed to a cell containment device, including a substrate having a contoured surface, a recess in the surface of the substrate, a cytophobic material connected to the surface of the substrate outside the recess and a cytophilic material connected to the recess.

US Patent:

20220374737, Nov 24, 2022

Filed:

May 24, 2021

Appl. No.:

17/328451

Inventors:

- San Francisco CA, US
Shravan SUNKADA - Kensington CA, US
Christopher CHEN - San Francisco CA, US
John SEARS - Berkeley CA, US

International Classification:

G06N 5/04
G06N 20/00
G07C 5/00
G06F 16/29

Abstract:

The disclosed embodiments provide techniques for scoring a driver or vehicle. In one embodiment, a method is disclosed comprising receiving metrics associated with a vehicle; generating a deviation vector based on the metrics and a plurality of aggregated values corresponding to the metrics; computing a driver update value based on the deviation vector and a plurality of model parameters, each of the plurality of model parameters corresponding to the metrics; and computing a driver score based on the driver update value, a previous score, and a learning rate.