Christopher Yeh Chen

US Patent:

20110159571, Jun 30, 2011

Filed:

Jan 6, 2011

Appl. No.:

12/986011

Inventors:

Michael A. Barry - Rochester MN, US
Christopher Y. Chen - Rochester MN, US

International Classification:

C12N 9/48
C07H 21/00
C07K 14/00
C07K 16/00
C12N 7/00

US Classification:

435212, 536 231, 536 2353, 530300, 5303873, 4352351

Abstract:

This document provides methods and materials involved in targeting adenoviruses. For example, this document provides nucleic acid molecules encoding a γ-carboxylated glutamic acid (GLA) domain of a factor X (fX) polypeptide, polypeptides having a GLA domain of a fX polypeptide, adenoviruses containing such nucleic acid molecules, adenoviruses containing such polypeptides, adenoviruses containing such nucleic acid molecules and such polypeptides, and compositions containing therapeutic adenoviral vectors and polypeptides having a GLA domain of an fX polypeptide. In addition, methods and materials for using adenoviruses as viral vectors to deliver nucleic acid to cells other than hepatocytes in vivo, methods and materials for using adenoviruses as vaccines, and methods and materials for using adenoviruses to treat cancer are provided.

US Patent:

20120058174, Mar 8, 2012

Filed:

Aug 17, 2011

Appl. No.:

13/211478

Inventors:

Jennifer L. West - Houston TX, US
Christopher S. Chen - Princeton NJ, US
Jordan S. Miller - Philadelphia PA, US
Michael T. Yang - Philadelphia PA, US

International Classification:

A61K 9/70
A61K 35/00
A61K 38/00
B29C 47/00
A61K 35/12
B29D 7/01
C03C 25/68
B05D 5/00
A61K 9/00
A61K 31/7088

US Classification:

424443, 424400, 424 931, 514 11, 514 44 R, 424 937, 264 458, 216 7, 427243, 264465

Abstract:

Methods of fabricating a substantially interconnected model vasculature, as well as compositions formed from such methods are provided. In some embodiments, the methods may comprise forming a non-woven fiber network comprising a plurality of fibers and a void space; backfilling the void space of the fiber network; and removing the fibers to form a substantially interconnected vascular network.

US Patent:

20150038598, Feb 5, 2015

Filed:

Jul 31, 2013

Appl. No.:

13/955897

Inventors:

Lixin You - Sugar Land TX, US
Shabbir Husain - Emeryville CA, US
Christopher M. Chen - Sugar Land TX, US

Assignee:

Chevron U.S.A. Inc. - San Ramon CA

International Classification:

C07C 1/04

US Classification:

518702, 518705, 422187

Abstract:

A synthesis gas conversion process and system are disclosed. Fresh syngas from a methane reformer is used as a sweep zone gas feed which is caused to flow across a water permselective membrane in a membrane reactor. The water permselective membrane is adjacent a synthesis gas conversion reaction zone in which synthesis gas is contacted with a catalyst and converted to effluent including water. Water is removed from the reaction zone through the membrane and passes out of the reactor with the sweep zone gas. The water is then removed from the sweep zone gas forming a modified gas feed which is fed to the reaction zone. The modified gas feed has a preferred H/CO ratio to feed into the reaction zone.