Christopher M Cimarusti from Clementon, NJ, age 81

Methods Of Processing Extracts Of A T. Wilfordii Hook F. Plant
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US Patent:

20140057008, Feb 27, 2014
Filed:

Mar 1, 2012
Appl. No.:

14/002529
Inventors:

George Paffendorf - Hackettstown NJ, US
Christopher M. Cimarusti - Manalapan NJ, US
International Classification:

A61K 36/37
US Classification:

424759
Abstract:

Products derived from the Hook F (TwHF) plant in the form of extracts are provided that are useful in preventing, treating, or ameliorating a symptom of an inflammatory disorder or an immune disorder, such as an auto-immune disease. Also provided are methods of freeze-drying a TwHF root and/or root portion, methods of debarking a freeze-dried TwHF root and/or root portion, methods of preparing and/or refining extracts in freely flowable solid form from freeze-dried debarked TwHF roots and/or root portions, and methods of using freely flowable solid extracts of TwHF in preventing, treating or ameliorating a symptom of an inflammatory disorder and/or an immune disorder.

Perhydrofluorenetetrol And Perhydrophenanthrenetetrol Derivatives
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US Patent:

41137264, Sep 12, 1978
Filed:

Feb 28, 1974
Appl. No.:

5/446837
Inventors:

Frederic Peter Hauck - Somerville NJ
Christopher Michael Cimarusti - Somerset NJ
Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:

C07D29502
C07D29508
C07D29514
US Classification:

544380
Abstract:

Compounds are provided having the structure ##STR1## wherein n is 1 or 2, n. sup. 1 is 0, 1 or 2 and n. sup. 2 is 0, 1, 2 or 3, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, R can be lower alkoxy, lower alkyl or cycloalkyl, R. sub. 8 can be hydrogen, lower alkyl, cycloalkyl, hydroxy, dialkylaminoalkyl or R. sub. 9 O(CH. sub. 2)q-. X is a single bond or a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.

Process For The Preparation Of (3S)-3-[[[2-(Protected Amino)-4-Thiazolyl]-Oxoacetyl]Amino]-2-Oxo-1-Azetidinesulfonic Acid And 4-Substituted Derivatives Thereof
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US Patent:

47044578, Nov 3, 1987
Filed:

Jun 21, 1982
Appl. No.:

6/390728
Inventors:

Jerome L. Moniot - Chester NJ
Christopher M. Cimarusti - Pennington NJ
Rita T. Fox - Princeton NJ
Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:

C07D41712
C07B 4306
C07B 4106
US Classification:

540355
Abstract:

A compund having the formula ##STR1## can be prepared by coupling a compound having the formula ##STR2## or a salt thereof, with a compound having the formula ##STR3## to yield a compound having the formula ##STR4## and oxidizing that compound to yield the desired compound; wherein R is hydrogen or an amino protecting group; R. sub. 1 is hydrogen, methly or ethyl; M. sup. sym. is an inorganic cation or a substituted ammonium ion; and M. sub. 1. sup. sym. is hydrogen, an organic cation, or a substituted ammonium ion.

Steroidal[16.Alpha.,17-B]1,4-Dioxanes And Steroidal[16.Alpha.,17-B]1,4-Dioxins
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US Patent:

39717720, Jul 27, 1976
Filed:

May 19, 1975
Appl. No.:

5/578695
Inventors:

Christopher M. Cimarusti - Hamilton NJ
Seymour D. Levine - North Brunswick NJ
Frank L. Weisenborn - Titusville NJ
Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:

C07J 500
US Classification:

26023955R
Abstract:

A series of novel steroidal [[16. alpha. ,17-b]1,4-dioxanes and steroidal [ 16. alpha. ,17-b]1,4-dioxins having useful anti-inflammatory properties is disclosed herein.

Process And Intermediates For Beta-Lactams Having Aminothiazole(Iminooxyacetic Acid)Acetic Acid Sidechains
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US Patent:

51946041, Mar 16, 1993
Filed:

Jun 29, 1990
Appl. No.:

7/546622
Inventors:

Theodor Denzel - Regensburg, DE
Christopher M. Cimarusti - Millstone NJ
Janak Singh - Lawrenceville NJ
Richard H. Mueller - Ringoes NJ
Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:

C07D41714
C07D50138
US Classification:

540222
Abstract:

Disclosed herein are processes for preparing a compound of the formula ##STR1## in which a novel compound of the formula ##STR2## is reacted with a beta lactam of the formula ##STR3## by treatment with a base, wherein the symbols are as defined in the specification.

Thio-.Beta.-Lactam Cephalosporins
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US Patent:

40187608, Apr 19, 1977
Filed:

Feb 20, 1976
Appl. No.:

5/659863
Inventors:

Christopher M. Cimarusti - Hamilton NJ
Paul Wojtkowski - Wilmington DE
Joseph E. Dolfini - Cincinnati OH
Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:

C07D50120
US Classification:

260243C
Abstract:

Thio-. beta. -lactam cephalosporins of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, trihaloethyl, alkali metal or alkaline earth metal; R. sub. 1 is hydrogen, lower alkyl, cycloalkyl, phenyl, phenoxy, phenyl-lower alkyl or certain heterocyclic groups; R. sub. 2 is hydrogen, amino, carboxy, hydroxy or ureido; and X is hydrogen, hydroxy, lower alkylthio, lower alkylthiadiazolyl, lower alkyltetrazolyl or lower alkanoyloxy, are useful as antimicrobial agents.

Indantetrol Derivatives
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US Patent:

40923185, May 30, 1978
Filed:

Mar 15, 1976
Appl. No.:

5/666983
Inventors:

Frederic Peter Hauck - Somerville NJ
Joyce Reid - Highland Park NJ
Venkatachala L. Narayanan - Hightstown NJ
Christopher M. Cimarusti - Hamilton NJ
Rudiger D. Haugwitz - Titusville NJ
Joseph E. Sundeen - Yardley PA
Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:

C07D21122
US Classification:

26029356
Abstract:

Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1 OR 2, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.

4,7-Dihydroindanyl Alkanols, Analogues Thereof And Their Corresponding Tosylates
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US Patent:

40440400, Aug 23, 1977
Filed:

Mar 15, 1976
Appl. No.:

5/667003
Inventors:

Frederic Peter Hauck - Somerville NJ
Joyce Reid - Highland Park NJ
Venkatachala L. Narayanan - Hightstown NJ
Christopher M. Cimarusti - Hamilton NJ
Rudiger D. Haugwitz - Titusville NJ
Joseph E. Sundeen - Yardley PA
Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:

C07C14368
C07C 3302
C07C 3532
C07C 3536
US Classification:

260456P
Abstract:

Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1, OR 2, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.