Christopher M Conrad

US Patent:

6677355, Jan 13, 2004

Filed:

Feb 13, 2002

Appl. No.:

10/049544

Inventors:

Christopher Alan Conrad - Allegan MI
Patrick Michael OBrien - Stockbridge MI
Daniel Fred Ortwine - Saline MI
Joseph Armand Picard - Canton MI
Drago Robert Sliskovic - Saline MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D30791

US Classification:

514320, 514422, 514432, 514459, 514468, 546195, 548531, 549 28, 549414, 549419

Abstract:

Compounds of the formula; are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also disclosed are methods for the preparation of such compounds, pharmaceutical compositions including the same, and methods of treating diseases in which matrix metalloproteinases are involved including multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurysm, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, osteoporosis, rheumatoid or osteoarthritis, renal disease, left ventricular dilation, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.