Christopher G Cooper

US Patent:

6720427, Apr 13, 2004

Filed:

May 13, 2002

Appl. No.:

10/144403

Inventors:

Mark A. Sanner - Old Saybrook CT
Chris J. Helal - Mystic CT
Christopher B. Cooper - Lawrenceville NJ

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D21722

US Classification:

548193, 546142, 546143, 546146, 546148, 546153, 546162, 546167, 5462707, 548190, 548191, 548195, 548196

Abstract:

The invention provides compounds of formula 1 wherein R , R , and R are as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inhibiting cdk5, cdk2, and GSK-3. Pharmaceutical compositions and methods comprising compounds of formula 1 for treating diseases and conditions comprising abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions and those affected by dopamine neurotransmission are described. Also described are pharmaceutical compositions and methods comprising compounds of formula 1 for treating male fertility and sperm motility; diabetes mellitus; impaired glucose tolerance; metabolic syndrome or syndrome X; polycystic ovary syndrome; adipogenesis and obesity; myogenesis and frailty, for example age-related decline in physical performance; acute sarcopenia, for example muscle atrophy and/or cachexia associated with burns, bed rest, limb immobilization, or major thoracic, abdominal, and/or orthopedic surgery; sepsis; hair loss, hair thinning, and balding; and immunodeficiency.

US Patent:

20020103185, Aug 1, 2002

Filed:

Aug 28, 2001

Appl. No.:

09/941001

Inventors:

Mark Sanner - Old Saybrook CT, US
Chris Helal - Mystic CT, US
Christopher Cooper - Lawrenceville NJ, US
Travis Wager - New London CT, US

International Classification:

A61K031/55
A61K031/454
C 07D 4 3/02
A61K031/415

US Classification:

514/217090, 514/407000, 514/326000, 540/603000, 548/364100, 548/367400, 546/211000

Abstract:

The invention provides compounds of formula 1 wherein R, R, R, and Rare as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inhibiting cdk5, cdk2, and GSK-3. Pharmaceutical compositions and methods comprising compounds of formula 1 for treating and preventing diseases and conditions comprising abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions and those affected by dopamine neurotransmission. Also described are pharmaceutical compositions and methods comprising compounds of formula 1 for treating male fertility and sperm motility; diabetes mellitus; impaired glucose tolerance; metabolic syndrome or syndrome X; polycystic ovary syndrome; adipogenesis and obesity; myogenesis and frailty, for example age-related decline in physical performance; acute sarcopenia, for example muscle atrophy and/or cachexia associated with burns, bed rest, limb immobilization, or major thoracic, abdominal, and/or orthopedic surgery; sepsis; hair loss, hair thinning, and balding; and immunodeficiency.

US Patent:

20040192746, Sep 30, 2004

Filed:

Apr 5, 2004

Appl. No.:

10/818876

Inventors:

Mark Sanner - Old Saybrook CT, US
Chris Helal - Mystic CT, US
Christopher Cooper - Lawrenceville NJ, US

Assignee:

Pfizer Inc

International Classification:

C07D277/18
A61K031/426

US Classification:

514/370000, 548/190000

Abstract:

The invention provides compounds of formula 1 wherein R, R, and Rare as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inhibiting cdk5, cdk2, and GSK-3. Pharmaceutical compositions and methods comprising compounds of formula 1 for treating diseases and conditions comprising abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions and those affected by dopamine neurotransmission are described. Also described are pharmaceutical compositions and methods comprising compounds of formula 1 for treating male fertility and sperm motility; diabetes mellitus; impaired glucose tolerance; metabolic syndrome or syndrome X; polycystic ovary syndrome; adipogenesis and obesity; myogenesis and frailty, for example age-related decline in physical performance; acute sarcopenia, for example muscle atrophy and/or cachexia associated with burns, bed rest, limb immobilization, or major thoracic, abdominal, and/or orthopedic surgery; sepsis; hair loss, hair thinning, and balding; and immunodeficiency.

US Patent:

20060149066, Jul 6, 2006

Filed:

Feb 24, 2006

Appl. No.:

11/361882

Inventors:

Mark Sanner - Old Saybrook CT, US
Chris Helal - Mystic CT, US
Christopher Cooper - Lawrence NJ, US
Frank Menniti - Mystic CT, US
Patricia Seymour - Westerly RI, US
Michael Ahlijanian - Mystic CT, US
Anabella Villalobos - Niantic CT, US

International Classification:

C07D 403/02

US Classification:

544405000, 546272700, 546169000, 548311100

Abstract:

The invention provides compounds of formula 1 wherein R, R, R, and Rare as defined, and their pharmaceutically acceptable salts. Compounds of formula 1 are indicated to have activity inhibiting cdk5, cdk2, and GSK-3. Pharmaceutical compositions and methods comprising compounds of formula 1 for treating and preventing diseases and conditions comprising abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions and those affected by dopamine neurotransmission. Also described are pharmaceutical compositions and methods comprising compounds of formula 1 for treating male fertility and sperm motility; diabetes mellitus; impaired glucose tolerance; metabolic syndrome or syndrome X; polycystic ovary syndrome; adipogenesis and obesity; myogenesis and frailty, for example age-related decline in physical performance; acute sarcopenia, for example muscle atrophy and/or cachexia associated with burns, bed rest, limb immobilization, or major thoracic, abdominal, and/or orthopedic surgery; sepsis; hair loss, hair thinning, and balding; and immunodeficiency.

US Patent:

60432381, Mar 28, 2000

Filed:

Aug 15, 1997

Appl. No.:

8/912091

Inventors:

Christopher B. Cooper - Groton CT
Joseph P. Lyssikatos - Gales Ferry CT
Donald W. Mann - Voluntown CT
Scott J. Hecker - Los Gatos CA

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D22316
A61K 3155

US Classification:

514213

Abstract:

A compound of the formula ##STR1## wherein a, V, X, Y, Z, R. sup. 1, R. sup. 2, R. sup. 3 and R. sup. 4 are as defined above, useful in (a) the treatment of myelosuppression including suppression associated with cancer chemotherapy as well as activation of the immune system for the treatment of cancer or (b) prevention and treatment of viral, fungal, bacterial and parasitic infectious diseases.

US Patent:

20210371609, Dec 2, 2021

Filed:

Nov 6, 2017

Appl. No.:

16/760497

Inventors:

- Leverkusen, DE
- Pittsburgh PA, US
Klaus Meyer - Dormagen, DE
Kira Planken - Goch, DE
Stefan Janke - Brüggen, DE
Christopher Cooper - East Lyme CT, US

International Classification:

C08J 5/18
C08K 5/00
C08K 5/3475
C08K 5/3492
C08L 69/00
C08K 5/12
C08K 3/013

Abstract:

The present invention relates to a plastic film having reduced UV activity, to particular embodiments of such plastic films in the form of coextruded films, layer constructions comprising the plastic film according to the invention, and to security documents, preferably identification documents, comprising such plastic films.

US Patent:

20170113391, Apr 27, 2017

Filed:

Jun 2, 2015

Appl. No.:

15/315423

Inventors:

- Pittsburgh PA, US
William Bodde - Belchertown MA, US
Zhizhong Liu - Wilbraham MA, US
Christopher Cooper - East Lyme CT, US

International Classification:

B29C 47/00
B29C 65/00
B29C 65/08

Abstract:

The present invention provides a continuous process comprising, extruding two or more layers of a thermoplastic polyurethane film, welding the two or more layers of film at a first edge in a machine direction and simultaneously slitting the welded film with an angular section of an anvil blade and winding the welded, slitted thermoplastic polyurethane film onto a roller. The resultant thermoplastic polyurethane film in tubular form may find use in medical applications such as coverings on robotic arms used for performing surgery (by proxy).