Christopher J Deur

US Patent:

20040019210, Jan 29, 2004

Filed:

Jul 17, 2003

Appl. No.:

10/621983

Inventors:

Cleo Chivikas Connolly - Livonia MI, US
Christopher Deur - Ann Arbor MI, US
James Hamby - Ann Arbor MI, US
Denton Hoyer - Dexter MI, US
Chris Limberakis - Saline MI, US
Jessica Reed - Ann Arbor MI, US
Mel Schroeder - Dexter MI, US
Clarke Taylor - Ann Arbor MI, US

International Classification:

C07D487/02
C07D475/02
C 07D 4 3/02

US Classification:

544/256000, 544/257000, 544/284000, 544/350000, 544/363000

Abstract:

This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines, and pyridopyrazines of the general formula: that inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediate compounds for their synthesis, as well as pharmaceutical compositions and methods for their use in treating, inhibiting or preventing maladies associated with cell proliferative disorders, including angiogenesis, atherosclerosis, restenosis, and cancer.

US Patent:

20050124668, Jun 9, 2005

Filed:

Sep 24, 2004

Appl. No.:

10/949908

Inventors:

Christopher Deur - Ann Arbor MI, US
Kevin Henegar - Ann Arbor MI, US
Christine Kolz - Dexter MI, US
Jonathan Miller - Ann Arbor MI, US
Augastine Osuma - Canton MI, US
Mark Plummer - Dexter MI, US
Brian Samas - Ann Arbor MI, US
Jacob Schwarz - Ann Arbor MI, US
Andrew Thorpe - Whitmore Lake MI, US
David Wustrow - Ann Arbor MI, US

International Classification:

A61K031/44
C07D213/55
A61K031/277
A61K031/198

US Classification:

514357000, 514522000, 514567000, 514561000, 558410000, 562443000, 546335000

Abstract:

Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.