Christopher D Dillon

US Patent:

20050251872, Nov 10, 2005

Filed:

Sep 5, 2003

Appl. No.:

10/655872

Inventors:

James Bear - Durham NC, US
Christopher Dillon - Cambridge MA, US
Douglas Rubinson - Cambridge MA, US
Luk Van Parijs - Falmouth MA, US

International Classification:

A01K067/00
C12N007/00
C12N015/867

US Classification:

800008000, 435456000, 435235100

Abstract:

The present invention provides new lentiviral vectors, including lentiviral transfer plasmids and infectious lentiviral particles. Lentiviral vectors of the invention were designed to offer a number of desirable features including reduced size, convenient cloning sites (including multiple cloning sites and sites for particularly useful restriction enzymes), loxP sites, self-inactivating LTRs, etc. Certain of the vectors are optimized for expression of reporter genes and/or for expression of siRNAs or shRNAs within eukaryotic cells. The invention also provides three and four plasmid lentiviral expression systems. In addition, the invention provides a variety of methods for using the vectors including gene silencing in cells and transgenic animals, and methods of treating disease.

US Patent:

20130103074, Apr 25, 2013

Filed:

Oct 9, 2012

Appl. No.:

13/648177

Inventors:

Cornell University - New York NY, US
Jeffery Milsom - New York NY, US
J. Frederick Cornhill - New York NY, US
Kevin Thomas Smith - Stamford CT, US
Tuan Anh Nguyen - Woburn MA, US
Darren Schneider - New York NY, US
Christopher Dillon - New York NY, US
Gabe Greeley - Cambridge MA, US
Rainuka Gupta - Cambridge MA, US
Jeremy Van Hill - Cambridge MA, US
Leslie Johnston - Cambridge MA, US
Matt DeNardo - Cambridge MA, US
Rahul Sathe - Cambridge MA, US

Assignee:

CORNELL UNIVERSITY - New York NY

International Classification:

A61B 17/12

US Classification:

606200

Abstract:

A device comprising a single closed loop of elastic filament configurable between (i) a first configuration for movement along a blood vessel; and (ii) a second configuration for lodging within a blood vessel, the second configuration providing a single flow-restricting face sized and configured to cover the mouth of the aneurysm and obstruct blood flow to the aneurysm while permitting substantially normal blood flow through the blood vessel, with the degree of obstruction at the mouth of the aneurysm being such that the aneurysm thromboses when the face is positioned over the aneurysm, the flow-restricting face comprising a plurality of lengths of the closed loop of filament disposed in close proximity to one another in a switchback configuration, and at least one leg for holding the flow-restricting face adjacent the mouth of the aneurysm, the leg configured so as to maintain substantially normal blood flow through the blood vessel.

US Patent:

20220175221, Jun 9, 2022

Filed:

Aug 3, 2021

Appl. No.:

17/392897

Inventors:

- Buckinghamshire, GB
Jeffrey Milsom - New York NY, US
Sameer Sharma - New York NY, US
Tuan Anh Nguyen - Woburn MA, US
Christopher Dillon - Underhill VT, US
Gabriel Greeley - Somerville MA, US
Rahul Sathe - Needham MA, US
Matthew DeNardo - Melrose MA, US
Ashley Whitney - Boston MA, US
Jeremy Van Hill - Somerville MA, US
Anthony Assal - Jamaica NY, US
Stephen Evans - Westford MA, US
Timothy Robinson - Sandown NH, US
Alan Fortunate - Watertown MA, US
Audrey Bell - Alton MA, US
Richard Yazbeck - Norwell MA, US
Brian David Chouinard - Lynn MA, US
Phal kun Chan - Brighton MA, US
William Rebh - Shrewsbury MA, US

International Classification:

A61B 1/00
A61B 1/31
A61M 25/10

Abstract:

Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the axial opening is closed down.

US Patent:

20210321858, Oct 21, 2021

Filed:

Dec 29, 2020

Appl. No.:

17/137019

Inventors:

- New York NY, US
Jeffery Milsom - New York NY, US
Sameer Sharma - New York NY, US
Tuan Anh Nguyen - Woburn MA, US
Christopher Dillon - Underhill VT, US
Gabriel Greeley - Cambridge MA, US
Rahul Sathe - Somerville MA, US
Matthew DeNardo - Melrose MA, US
Ashley Whitney - Somerville MA, US
Jeremy Van Hill - Somerville MA, US
Anthony Assal - Bronx NY, US

International Classification:

A61B 1/00
A61M 25/10
A61B 1/31

Abstract:

Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; a proximal balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the proximal balloon; a push tube slidably mounted to the sleeve; and a distal balloon secured to the distal end of the push tube, the interior of the distal balloon being in fluid communication with the push tube, wherein the distal balloon is capable of assuming a deflated condition and an inflated condition, and further wherein when the distal balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and when the distal balloon is in its inflated condition, the axial opening is closed down.

US Patent:

20190343372, Nov 14, 2019

Filed:

Dec 11, 2018

Appl. No.:

16/215843

Inventors:

- Buckinghamshire, GB
Jeffrey Milsom - New York NY, US
Sameer Sharma - New York NY, US
Tuan Anh Nguyen - Woburn MA, US
Christopher Dillon - Underhill VT, US
Gabriel Greeley - Somerville MA, US
Rahul Sathe - Needham MA, US
Matthew DeNardo - Melrose MA, US
Ashley Whitney - Boston MA, US
Jeremy Van Hill - Somerville MA, US
Anthony Assal - Jamaica NY, US
Stephen Evans - Westford MA, US
Timothy Robinson - Sandown NH, US
Alan Fortunate - Watertown MA, US
Audrey Bell - Alton MA, US
Richard Yazbeck - Norwell MA, US
Brian David Chouinard - Lynn MA, US
Phal kun Chan - Brighton MA, US
William Rebh - Shrewsbury MA, US

International Classification:

A61B 1/00
A61B 1/31
A61M 25/10

Abstract:

Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the axial opening is closed down.

US Patent:

20160278626, Sep 29, 2016

Filed:

Jun 3, 2016

Appl. No.:

15/172385

Inventors:

- London, GB
Jeffrey Milsom - New York NY, US
Sameer Sharma - Cambridge MA, US
Tuan Anh Nguyen - Woburn MA, US
Christopher Dillon - New York NY, US
Gabriel Greeley - Cambridge MA, US
Rahul Sathe - Somerville MA, US
Matthew DeNardo - Watertown MA, US
Ashley Whitney - Somerville MA, US
Jeremy Van Hill - Boston MA, US
Anthony Assal - Ithaca NY, US
Stephen Evans - Marlborough MA, US
Timothy Robinson - Marlborough MA, US
Alan Fortunate - Marlborough MA, US
Audrey Bell - Marlborough MA, US
Richard Yazbeck - Marlborough MA, US
Brian David Chouinard - Marlborough MA, US
Phala Chan - Marlborough MA, US
William Rebh - Marlborough MA, US

International Classification:

A61B 1/32
A61B 1/018
A61B 1/00

Abstract:

Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; an aft balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the aft balloon; a pair of hollow push tubes slidably mounted to the sleeve, the pair of hollow push tubes being connected to one another at their distal ends with a raised push tube bridge, the raised push tube bridge being configured to nest an endoscope therein; and a fore balloon secured to the distal ends of the pair of hollow push tubes, the interior of the fore balloon being in fluid communication with the interiors of the pair of hollow push tubes, wherein the fore balloon is capable of assuming a deflated condition and an inflated condition, and further wherein (i) when the fore balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and (ii) when the fore balloon is in its inflated condition, the axial opening is closed down.

US Patent:

20150150436, Jun 4, 2015

Filed:

Feb 11, 2015

Appl. No.:

14/619845

Inventors:

- Ithaca NY, US
Jeffrey Milsom - New York NY, US
Sameer Sharma - Cambridge MA, US
Tuan Anh Nguyen - Woburn MA, US
Christopher Dillon - New York NY, US
Gabriel Greeley - Cambridge MA, US
Rahul Sathe - Somerville MA, US
Matthew DeNardo - Watertown MA, US
Ashley Whitney - Somerville MA, US
Jeremy Van Hill - Boston MA, US
Anthony Assal - Ithaca NY, US

International Classification:

A61B 1/00
A61B 1/31
A61B 1/018
A61M 25/10
A61B 1/01

Abstract:

Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; a proximal balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the proximal balloon; a push tube slidably mounted to the sleeve; and a distal balloon secured to the distal end of the push tube, the interior of the distal balloon being in fluid communication with the push tube, wherein the distal balloon is capable of assuming a deflated condition and an inflated condition, and further wherein when the distal balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and when the distal balloon is in its inflated condition, the axial opening is closed down.