Christopher C Dodson

US Patent:

20130225524, Aug 29, 2013

Filed:

Nov 3, 2011

Appl. No.:

13/883023

Inventors:

Deping Chai - Collegeville PA, US
Mariela Colon - Collegeville PA, US
Christopher Dodson - Collegeville PA, US
Kevin J. Duffy - Collegeville PA, US
Antony Nicholas Shaw - Collegeville PA, US

International Classification:

A61K 31/506
A61K 31/4709
A61K 31/4706
A61K 31/496
A61K 31/513
A61K 31/69
A61K 31/517
C07D 401/10
C07D 413/10
C07D 215/54
C07D 401/14
C07D 405/14
C07D 471/04
C07F 5/02
C07D 413/14
A61K 45/06

US Classification:

514 64, 544310, 546161, 544363, 544333, 546113, 546 13, 544284, 544123, 514274, 514313, 51425306, 514256, 514300, 51426621

Abstract:

The invention is directed to substituted quinoline derivatives. Specifically, the invention is directed to compounds according to Formula I:wherein R, R, R, R, and Rare defined herein.The compounds of the invention are inhibitors of lactate dehydrogenase A and can be useful in the treatment of cancer and diseases associated with tumor cell metabolism, such as cancer, and more specifically cancers of the breast, colon, prostate and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting lactate dehydrogenase A activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.