Christopher Levar Douglas

US Patent:

6723560, Apr 20, 2004

Filed:

Oct 8, 1998

Appl. No.:

09/168791

Inventors:

Elliott Richelson - Ponte Vedra Beach FL
Beth Marie Tyler - Neptune Beach FL
Bernadette Marie Cusack - Jacksonville FL
Christopher Lee Douglas - Jacksonville FL
Karen Jansen - Jacksonville FL

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

C07H 2104

US Classification:

435375, 435 6, 435325, 435377, 514 44, 536 187, 536 241, 536 245

Abstract:

The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal. Further, the invention provides methods and materials for screening potential PNA oligomers for the ability to engender a sequence specific biological response.

US Patent:

6743627, Jun 1, 2004

Filed:

Jan 30, 1998

Appl. No.:

09/016685

Inventors:

Elliott Richelson - Ponte Vedra Beach FL
Beth Marie Tyler - Neptune Beach FL
Daniel J. McCormick - Rochester MN
Bernadette Marie Cusack - Jacksonville Beach FL
Clark V. Hoshall - Ponte Vedra Beach FL
Christopher Lee Douglas - Jacksonville FL
Karen Jansen - Jacksonville FL

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

C07K 2104

US Classification:

435375, 435 6, 435377, 536 187, 536 241, 536 245, 514 44

Abstract:

The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.

US Patent:

6989270, Jan 24, 2006

Filed:

Oct 8, 1998

Appl. No.:

09/168714

Inventors:

Elliott Richelson - Ponte Vedra Beach FL, US
Beth Marie Tyler - Neptune Beach FL, US
Bernadette Marie Cusack - Jacksonville Beach FL, US
Christopher Lee Douglas - Jacksonville FL, US
Karen Jansen - Jacksonville FL, US

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

C07H 21/04
C12N 15/00
A61K 48/00

US Classification:

435375, 435 6, 435377, 435455, 514 44, 514 2, 536 187, 536 241, 536 245

Abstract:

The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal. Further, the invention provides methods and materials for screening potential PNA oligomers for the ability to engender a sequence specific biological response.

US Patent:

20040224889, Nov 11, 2004

Filed:

Mar 12, 2004

Appl. No.:

10/799238

Inventors:

Elliott Richelson - Ponte Vedra Beach FL, US
Beth Tyler - Neptune Beach FL, US
Daniel McCormick - Rochester MN, US
Bernadette Cusack - Jacksonville Beach FL, US
Clark Hoshall - Ponte Vedra Beach FL, US
Christopher Douglas - Jacksonville FL, US
Karen Jansen - Jacksonville FL, US

Assignee:

Mayo Foundation for Medical Education and Research, a Minnesota corporation

International Classification:

A61K048/00

US Classification:

514/012000, 514/044000

Abstract:

The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods and materials of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. In addition, the invention provides methods and materials for orally administering PNA oligomers to animals such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. The invention also provides sense and antisense PNA oligomers that modulate transcription and translation, respectively. The invention also provides mismatch PNA oligomers that modulate the degree of an engendered biological response. In addition, the invention provides methods and materials for detecting PNA oligomers within a biological sample collected from an animal. Further, the invention provides methods and materials for screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, the invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.

US Patent:

6472209, Oct 29, 2002

Filed:

Oct 17, 1997

Appl. No.:

08/953269

Inventors:

Elliott Richelson - Ponte Vedra Beach FL
Beth Marie Tyler - Neptune Beach FL
Daniel J. McCormick - Rochester MN
Bernadette Marie Cusack - Jacksonville Beach FL
Clark V. Hoshall - Ponte Vedra Beach FL
Christopher Lee Douglas - Jacksonville FL
Karen Jansen - Jacksonville FL

Assignee:

Mayo Foundation for Medical Education and Research - Rochester MN

International Classification:

C07H 2104

US Classification:

435375, 435 6, 435377, 514 44, 536 245, 536 241, 536 187

Abstract:

The invention involves methods and materials for extracellularly administering PNA oligomers to living cells. Specifically, the invention provides methods of treating living cells with PNA oligomers such that the oligomers cross biological barriers and engender a biological response in a sequence specific manner. This invention also provides methods of screening potential PNA oligomers for the ability to engender a sequence specific biological response. Further, this invention provides methods of identifying the function of polypeptides and of determining the relative turnover rate of functional polypeptides.