Christopher J Duke

US Patent:

20210393674, Dec 23, 2021

Filed:

Sep 19, 2016

Appl. No.:

15/761101

Inventors:

- San Diego, CA
Christopher Duke - San Diego CA, US

International Classification:

A61K 33/00
A61K 31/136
A61K 31/704
A61K 31/66
A61K 31/121
A01N 33/12
A01P 1/00
C07C 51/34
C07C 45/40
C07C 225/36
C07H 15/244

Abstract:

Provided is an inactive compound that is activated by reaction with ozone into an active compound having a carbonyl oxygen. Also provided is a method of activating the above inactive compounds. Further provided is a method of treating a disease or condition in a subject using the above compound at a site that is not exposed to atmospheric ozone. Additionally provided is a method of determining internal ozonolysis in a subject using the above compound. Also provided is a molecule less than 1000 mw, having a double bond that is reactive with ozone, and forms a nontoxic compound after reacting with ozone. Further provided is a method of degrading ozone.

US Patent:

20200383964, Dec 10, 2020

Filed:

Dec 5, 2018

Appl. No.:

16/770553

Inventors:

Christopher Duke - San Diego CA, US

International Classification:

A61K 31/4433
A61K 9/127
A61K 31/4422

Abstract:

Provided herewith is a compound that reacts with a reactive lipid species to form a non-toxic product or an active product. Also provided is a method of reducing a reactive lipid species. Additionally provided is a method of treating a mitochondrion in a patient comprising a mitochondrial dysfunction. In other embodiments, a compound is provided that reacts with an activating agent present at a mitochondrion to form an active product that inhibits or enhances the opening of a mitochondrial permeability transition pore (MPTP). In additional embodiments, a method of inhibiting or enhancing the opening of an MPTP is provided. Further provided is a nonpolar compound capable of crossing the blood-brain barrier (BBB) into the central nervous system (CNS).

US Patent:

20200102281, Apr 2, 2020

Filed:

Nov 29, 2017

Appl. No.:

16/467965

Inventors:

Christopher Duke - San Diego CA, US

International Classification:

C07D 311/72
C07C 29/48
C07C 403/14
C07C 45/40
C07C 67/05
C08L 29/10
C08L 33/14

Abstract:

Provided are compounds that generate a peroxide when they react with ozone in the presence of water. Additionally, alkyne compounds reactive with a free radical, a reactive oxygen species (ROS) or another reactive species are provided. Also provided are enol ether, enamine, and vinal thioester compounds reactive with a free radical, a strong acid, a reactive oxygen species (ROS) or another reactive species. Additionally provided are compounds reactive with a free radical, an ROS or another reactive species. The compounds comprise a conjugated moiety operably joined to an alkene moiety and a resonance-transmitting moiety, wherein the resonance-transmitting moiety transmits an electron through the conjugated moiety to the alkene moiety, which reacts with the free radical, an ROS or another reactive species. Also provided are methods of decomposing a free radical, an ROS or another reactive species. The methods comprise contacting the free radical or ROS with any of the above compounds. Also provided are methods of using any of the compounds described herein, and compositions comprising those compounds. Additionally provided are methods of producing the above compounds.

US Patent:

20170320052, Nov 9, 2017

Filed:

Jun 5, 2017

Appl. No.:

15/614250

Inventors:

- San Diego CA, US
Christopher Duke - San Diego CA, US

International Classification:

B01J 41/12
B01J 41/13
B01D 53/66

Abstract:

Disclosed herein are ozone reactive polymers comprising a structural repeat unit represented by the following formula XLI:wherein A is absent or a linking group selected from the group consisting of substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, substituted or unsubstituted arylalkylene, and substituted or unsubstituted heteroarylalkylene; each of Rand Ris, independently, selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, and substituted or unsubstituted heteroarylalkyl; and wherein the structural repeat unit comprises at least 10% by weight of the polymer.

US Patent:

20160038931, Feb 11, 2016

Filed:

Aug 8, 2015

Appl. No.:

14/821710

Inventors:

- San Diego CA, US
Christopher Duke - San Diego CA, US

International Classification:

B01J 41/12
B01D 53/02

Abstract:

Disclosed herein are ozone reactive polymers comprising a structural repeat unit represented by the following formula XLI:

US Patent:

20140318732, Oct 30, 2014

Filed:

Apr 26, 2013

Appl. No.:

13/871038

Inventors:

Christopher Duke - San Diego CA, US
Margaret Hoban - Duxbury MA, US
Cari Schroeder - San Diego CA, US
Matthew Duke - Huntington Beach CA, US

International Classification:

E02B 1/00

US Classification:

165 111, 165 45

Abstract:

A method of slowing melting of the polar ice shelves is provided. The method comprises conveying air underneath the ice shelf, at least temporarily, forming an insulating layer between the ice of the ice shelf and the sea water below. The method may be carried out by drilling a hole through the ice shelf and conveying air through the hole until it reaches the water. The buoyancy of the air will position it between the sea water and ice, thereby insulating the ice from the melting sea water.