Christopher J. Fielding - Mill Valley CA Phoebe E. Fielding - Mill Valley CA
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
C12Q 160
US Classification:
435 11
Abstract:
This invention provides for methods of reducing cholesterol uptake by a cell. The invention is premised in part on the discovery of a new mechanisms by which free cholesterol (FC) is internalized into a cell from low-density lipoproteins. Inhibition of this mechanism reduces the internalization of free cholesterol into cholesterol transport vesicles thereby reducing free cholesterol content of the cell at physiological concentrations of LDL and HDL.
This invention provides a novel intracellular recycling free cholesterol pathway whose activity is required for cell division. The pathway provides the cholesterol needed for cell division prior to separation of daughter cells (mitosis). The new pathway offers several targets from pharmaceutical intervention, either via small molecules (such as sterol analogs) or by molecular engineering (preventing the cell from accumulating cholesterol by promoting free cholesterol efflux by transfection of caveolin cDNA).
An international team of scientists, including UConn Department of Earth Sciences researchers Professor and Department Head Tracy Frank and Professor Christopher Fielding, are working to understand the cause and how the events of the LPME unfolded by focusing on mercury from Siberian volcanoes that
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