Christopher W Holmes

US Patent:

6368874, Apr 9, 2002

Filed:

Nov 17, 1999

Appl. No.:

09/442427

Inventors:

Mark A. Gallop - Los Altos CA
Eric Gordon - Palo Alto CA
Zhi-Jie Ni - Sunnyvale CA
Derek MacLean - Los Altos CA
Christopher Holmes - Sunnyvale CA
William Fitch - Palo Alto CA
Nikhil Shah - Fremont CA

Assignee:

Affymax, Inc. - Palo Alto CA

International Classification:

G01N 33543

US Classification:

436518, 436501, 436528, 436 85, 435 71, 435DIG 1, 435DIG 2, 435DIG 14, 435DIG 15, 435DIG 16, 435DIG 17, 435DIG 18, 435DIG 21, 435DIG 49, 536 231

Abstract:

Disclosed are chemical encryption methods for determining the structure of compounds formed in situ on solid supports by the use of specific amines tags which, after compound synthesis, can be deencrypted to provide the structure of the compound found on the support.

US Patent:

6426357, Jul 30, 2002

Filed:

Jul 31, 2000

Appl. No.:

09/629180

Inventors:

Randall A. Scheuerman - Santa Clara CA
Stephen D. Yanofsky - Palo Alto CA
Christopher P. Holmes - Saratoga CA
Derek MacLean - Mountain View CA
Beatrice Ruhland - Los Altos CA
Ronald W. Barrett - Saratoga CA
Jay E. Wrobel - Lawrenceville NJ
Ariamala Gopalsamy - Mahwah NJ

Assignee:

Affymax, Inc. - Palo Alto CA

International Classification:

A61K 31427

US Classification:

514369, 548182, 548187

Abstract:

The present invention provides a compound of the formula: and methods for using the same, wherein R , R , R , R and X are those defined herein.

US Patent:

6468740, Oct 22, 2002

Filed:

Apr 8, 1998

Appl. No.:

09/057162

Inventors:

Christopher P. Holmes - Sunnyvale CA

Assignee:

Affymetrix, Inc. - Santa Clara CA

International Classification:

C12Q 168

US Classification:

435 6, 435 71, 435DIG 46, 435DIG 49, 436518, 536 253, 536 2531, 536 2532, 530334, 525542

Abstract:

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. In one particular embodiment, an array of rotated cyclic polymers is formed. In another embodiment, an array of polymers is formed based on a target polymer. The array includes systematically substituted versions of the target molecule. In another embodiment, rotated and systematically substituted cyclic polymers are formed on a substrate.

US Patent:

7084245, Aug 1, 2006

Filed:

May 12, 2004

Appl. No.:

10/844968

Inventors:

Christopher P. Holmes - Saratoga CA, US
Qun Yin - Palo Alto CA, US
Guy Lalonde - Woodside CA, US
Peter J. Schatz - Cupertino CA, US
David Tumelty - Sunnyvale CA, US
Balu Palani - Cupertino CA, US
Genet Zemede - Santa Clara CA, US

Assignee:

Affymax, Inc. - Palo Alto CA

International Classification:

A01N 43/40
A61K 38/00

US Classification:

530323, 514 9, 930 90

Abstract:

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

US Patent:

7414105, Aug 19, 2008

Filed:

Oct 27, 2005

Appl. No.:

11/261157

Inventors:

Christopher P. Holmes - Saratoga CA, US
Qun Yin - Palo Alto CA, US
Guy Lalonde - Woodside CA, US
Peter J. Schatz - Cupertino CA, US
David Tumelty - Sunnyvale CA, US
Balu Palani - Cupertino CA, US
Genet Zemede - Santa Clara CA, US

Assignee:

Affymax, Inc. - Palo Alto CA

International Classification:

A01N 43/40
A61K 38/00

US Classification:

530323, 514 9, 930 90

Abstract:

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

US Patent:

7528104, May 5, 2009

Filed:

May 12, 2004

Appl. No.:

10/555868

Inventors:

Christopher P. Holmes - Saratoga CA, US
Qun Yin - Palo Alto CA, US
Guy Lalonde - Woodside CA, US
Peter J. Schatz - Cupertino CA, US
David Tumelty - Sunnyvale CA, US
Balu Palani - Cupertino CA, US
Genet Zemede - Santa Clara CA, US

Assignee:

Affymax, Inc. - Palo Alto CA

International Classification:

A01N 43/40
A61K 38/00

US Classification:

514 2, 514 12, 514 13, 514 14, 530323, 530324, 530326, 530327, 5303882, 530402

Abstract:

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.

US Patent:

7700524, Apr 20, 2010

Filed:

Jan 11, 2002

Appl. No.:

10/466124

Inventors:

Christopher Holmes - Saratoga CA, US
Yijun Pan - Freemont CA, US

Assignee:

GE Healthcare Limited - Buckinghamshire

International Classification:

C40B 80/00

US Classification:

506 42, 506 32, 502159, 560150

Abstract:

Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula (I) wherein L is a linking group component; X is F, CL, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic sync) thesis are also provided.

US Patent:

7855175, Dec 21, 2010

Filed:

Jul 11, 2008

Appl. No.:

12/171610

Inventors:

Christopher P. Holmes - Saratoga CA, US
Qun Yin - Palo Alto CA, US
Guy Lalonde - Woodside CA, US
Peter J. Schatz - Cupertino CA, US
David Tumelty - San Diego CA, US
Palani Balu - Cupertino CA, US
Genet Zemede - San Jose CA, US

Assignee:

Affymax, Inc. - Palo Alto CA

International Classification:

A61K 38/00
A61K 51/00

US Classification:

514 2, 530300, 930 90, 424 141

Abstract:

The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.