Christopher M Horvath

US Patent:

6663863, Dec 16, 2003

Filed:

Mar 15, 2001

Appl. No.:

09/809739

Inventors:

Christopher J. Horvath - Taunton MA
Patricia E. Rao - Acton MA

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 39395

US Classification:

4241441, 4241301, 4241331, 4241371, 4241411, 4241431, 4241521, 4241531, 4241541, 4241721, 4241731, 4241841, 530350, 530395, 5303871, 5303873, 5303875, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875

Abstract:

The invention relates to a method of inhibiting stenosis or restenosis in a subject. In one embodiment, an agent which inhibits recruitment and/or adhesion of neutrophils and mononuclear cells to a site of vascular injury is administered to a subject in need thereof. In another embodiment, a first agent which inhibits recruitment and/or adhesion of neutrophils to a site of vascular injury, and a second agent which inhibits recruitment and/or adhesion of mononuclear cells to a site of vascular injury are administered to a subject in need thereof. In particular embodiments, the agents are antibodies or antigen-binding fragments thereof which bind to CD18 or CCR2.

US Patent:

8289327, Oct 16, 2012

Filed:

Sep 30, 2009

Appl. No.:

12/570085

Inventors:

Christopher Jon Horvath - San Francisco CA, US

Assignee:

Lucasfilm Entertainment Company Ltd. - San Francisco CA

International Classification:

G06T 17/00
G06T 13/00
G06G 7/48

US Classification:

345428, 345473, 703 6, 703 9

Abstract:

A system includes a computing device that includes a memory for storing a three-dimensional model that represents particles of a coarse fire simulation. The computing device also includes a graphics refiner for producing two-dimensional simulation segments from the three-dimensional model that represents particles of a coarse fire simulation. The separation distance between two or more of the two-dimensional simulation segments is based upon a level of spatial detail provided by the coarse fire simulation. The graphics refiner is configured to separately process the two-dimensional simulation segments to produce a detailed fire simulation.

US Patent:

20040101527, May 27, 2004

Filed:

Nov 17, 2003

Appl. No.:

10/716028

Inventors:

Christopher Horvath - Taunton MA, US

Assignee:

Millennium Pharmaceuticals, Inc., a Delaware corporation

International Classification:

A61K039/395

US Classification:

424/144100

Abstract:

The invention is based on the discovery that molecules (e.g. a monoclonal antibody or a portion thereof) which bind specifically with the CD18 subunit of a CD18-containing leukocyte cell-surface antigens (e.g. a cell-surface antigen such as Mac-1 which contains both CD18 and a form of CD11) can be used to inhibit, prevent, and alleviate vascular stenotic and restenotic lesions and symptoms and disorders associated with such lesions.

US Patent:

20050214299, Sep 29, 2005

Filed:

Sep 12, 2003

Appl. No.:

10/662061

Inventors:

Christopher Horvath - Taunton MA, US
Patricia Rao - Acton MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K039/395
A61M031/00

US Classification:

424152100, 424144100, 604500000

Abstract:

The invention relates to a method of inhibiting stenosis or restenosis in a subject. In one embodiment, an agent which inhibits recruitment and/or adhesion of neutrophils and mononuclear cells to a site of vascular injury is administered to a subject in need thereof. In another embodiment, a first agent which inhibits recruitment and/or adhesion of neutrophils to a site of vascular injury, and a second agent which inhibits recruitment and/or adhesion of mononuclear cells to a site of vascular injury are administered to a subject in need thereof. In particular embodiments, the agents are antibodies or antigen-binding fragments thereof which bind to CD18 or CCR2.

US Patent:

20150086546, Mar 26, 2015

Filed:

Dec 3, 2014

Appl. No.:

14/559787

Inventors:

- CAMBRIDGE MA, US
Christopher J. Horvath - Taunton MA, US
Walter Newman - Boston MA, US
Stephan T. Jones - Radlett, GB
Siobhan H. O'Brien - Bishops Stortford, GB
Theresa L. O'Keefe - Waltham MA, US

International Classification:

C07K 16/28

US Classification:

4241331, 5303873, 536 2353, 4353201, 435 696, 435375, 435328

Abstract:

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.