Christopher Lynn Larson

US Patent:

7863012, Jan 4, 2011

Filed:

Feb 17, 2004

Appl. No.:

10/780399

Inventors:

Galla Chandra Rao - Princeton Junction NJ, US
Christopher Larson - Media PA, US
Madeline Repollet - Fort Washington PA, US
Herman Rutner - Hatboro PA, US
Leon W. M. M. Terstappen - Huntingdon Valley PA, US
Shawn Mark O'Hara - Ambler PA, US
Steven Gross - Ambler PA, US

Assignee:

Veridex, LLC - Raritan NJ

International Classification:

A01N 1/02
G01N 33/574
G01N 33/553
G01N 33/00

US Classification:

435 723, 435 2, 435 721, 435 724, 435 794, 4352872, 436501, 436526, 436538, 436 10, 436175, 436177, 436813, 422 61, 422 73, 422101, 5333888, 5333897, 533413

Abstract:

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

US Patent:

20130013476, Jan 10, 2013

Filed:

Jul 6, 2011

Appl. No.:

13/177024

Inventors:

Richard Louis Knafelz - Charlotte NC, US
David Bowman Jones - , US
John DeZervos - Morresville NC, US
Robin Griffen Cobb - Virginia Beach VA, US
Christopher A. Larson - New York NY, US

Assignee:

Bank of America Corporation - Charlotte NC

International Classification:

G06Q 40/00

US Classification:

705 35

Abstract:

According to some embodiments, a system includes an interface and one or more processors. The interface receives a request from a user to move a first account associated with a first enterprise to a second enterprise where the user has at least one account. The processor(s) determine first configuration settings associated with the first account. The processor(s) create a second account at the second enterprise, select second configuration settings based on the first configuration settings, and apply the second configuration settings to the second account.

US Patent:

20210321613, Oct 21, 2021

Filed:

Jun 12, 2019

Appl. No.:

17/251005

Inventors:

- Cary NC, US
Vic Prasad - Leawood KS, US
Cameron Gibb - Apex NC, US
Christopher Lynn Larson - Cary NC, US

International Classification:

A01N 43/32
C07D 341/00

Abstract:

A process for preparation of thiocyclam base and salt. A method of manufacturing N,N-dimethyl-1,2,3-trithian-5-ylainine hydrochloride is described including the steps of: providing a mixture of thiosulfuric acid S, S′[2-(dimethylamino) trimethylene] ester monosodium salt and sodium hydroxide; adding an aqueous saline solution to the mixture of thiosulfuric acid S, S′-[-(dimethylamino) trimethylene] ester monosodium salt and sodium hydroxide; separating the phases of the mixture; collecting the solids from the mixture using filtration; washing the solids with organic solvent; and drying the solids, where the dried solids are methyl-1,2,3-trithian-5-ylamine hydrochloride, and where the yield of the N,N-dimethyl-1,2,3-trithian-5-ylamine hydrochloride is increased by incorporation of a body charge of diatomaceous earth into the saline addition step, forming a mixture of the diatomaceous C earth with the composition of this step, and filtering the charged mixture through a diatomaceous earth media prior to the separation step.

US Patent:

20200352167, Nov 12, 2020

Filed:

Jan 23, 2019

Appl. No.:

16/961377

Inventors:

- Cary NC, US
Christopher L. Larson - Cary NC, US
Cameron Seath Gibb - Apex NC, US

International Classification:

A01N 43/653
A01N 25/04
A01N 41/06
A01N 47/38

Abstract:

A flucarbazone sodium hemihydrate method and composition. A method of suppressing growth of grass and broadleaf weeds is described including applying to said weeds at least one dust-free composition comprising flucarbazone sodium-hemihydrate as an active ingredient. A method for preparing flucarbazone sodium-hemihydrate is also described including treating 4,5-dihydro-3-methoxy-4-methyl-5-oxo-N-[[2-(trifluoromethoxy)phenyl]sulfonyl]-1H-1,2,4-triazole-1-carboxamide (MSU) with aqueous sodium hydroxide under pH-controlled conditions; and confirming that a hemihydrate flucarbazone sodium has been obtained.

US Patent:

20200255459, Aug 13, 2020

Filed:

Apr 28, 2020

Appl. No.:

16/860182

Inventors:

- Cary NC, US
David HUANG - KUNSHAN, CN
Kamal KATARIA - Maharashtra, IN
Christopher Lynn LARSON - Cary NC, US
Cameron Seath GIBB - Apex NC, US
Stephen CORNES - American Canyon CA, US

International Classification:

C07F 9/24

Abstract:

Preparation of O,O-dimethyl phosphoramidothioate and O,O-dimethyl phosphoroamidothioate. A process of making O,O-dimethyl phosphoroamidothioate is described including reacting sulfur with PClto form PSCl, reacting the PSClformed with methanol to form O-methyl phosphorodichloridothioate, and reacting the O-methyl phosphorodichloridothioate formed with methyl lye to form O,O-dimethyl phosphorochloridothioate in solution in CHCl, and reacting the O,O-dimethyl phosphorochloridothioate formed with sodium hydroxide and ammonium hydroxide to form O,O-dimethyl phosphoroamidothioate in solution in CHCl. Reacting the O,O-dimethyl phosphoroamidothioate formed with catalytic dimethyl sulfate to form methamidophos and reacting the methamidophos formed with acetic anhydride to form N-(methoxy-methylsulfanylphosphoryl) acetamide is also described. Throughout the process, the O,O-dimethyl phosphorochloridothioate and the O,O-dimethyl phosphoroamidothioate formed are maintained in solution in CHClat all times.

US Patent:

20200216408, Jul 9, 2020

Filed:

Mar 4, 2020

Appl. No.:

16/808871

Inventors:

- Cary NC, US
Christopher L. Larson - Cary NC, US
Mark T. Singleton - Morris CT, US
Kamal L. Kataria - Maharashtra State, IN
Samantha Besse - Daban, FR
Thomas C. Lovelace - Apex NC, US
Chandra S. Kanugala - Telangana, IN
Srinivas Vollala - Telangana, IN
Balraju Vadla - Telangana, IN

International Classification:

C07D 341/00
A01N 43/32
A01N 43/80

Abstract:

A method for manufacturing an insecticidal compound and insecticidal compositions comprising the insecticidal compound and methods of use are presented herein. The manufacturing method presented herein allows for a high purity grade of thiocyclam hydrochloride to be synthesized. The insecticidal compositions comprising the thiocyclam hydrochloride can be used for prevention of crop destruction by insects. The use of thiocyclam hydrochloride in insecticidal compositions as described herein can achieve greater efficacy than previously known insecticides, by eliminating the insect pests more reliably and efficiently.

US Patent:

20200216409, Jul 9, 2020

Filed:

Mar 4, 2020

Appl. No.:

16/808905

Inventors:

- Cary NC, US
Christopher L. Larson - Cary NC, US
Mark T. Singleton - Morris CT, US
Kamal L. Kataria - Maharashtra State, IN
Samantha Besse - Daban, FR
Thomas C. Lovelace - Apex NC, US
Chandra S. Kanugala - Telangana, IN
Srinivas Vollala - Telangana, IN
Balraju Vadla - Telangana, IN

International Classification:

C07D 341/00
A01N 43/32
A01N 43/80

Abstract:

A method for manufacturing an insecticidal compound and insecticidal compositions comprising the insecticidal compound and methods of use are presented herein. The manufacturing method presented herein allows for a high purity grade of thiocyclam hydrochloride to be synthesized. The insecticidal compositions comprising the thiocyclam hydrochloride can be used for prevention of crop destruction by insects. The use of thiocyclam hydrochloride in insecticidal compositions as described herein can achieve greater efficacy than previously known insecticides, by eliminating the insect pests more reliably and efficiently.

US Patent:

20200157043, May 21, 2020

Filed:

Nov 15, 2019

Appl. No.:

16/685703

Inventors:

- Cary NC, US
Vic PRASAD - Leawood KS, US
Christopher Lynn LARSON - Cary NC, US
Cameron Seath GIBB - Apex NC, US
Kirit DESAI - Gujarat, IN
Ashwani GUPTA - Gujarat, IN
Girish SISODE - Gujarat, IN

Assignee:

Arysta LifeScience Inc. - Cary NC

International Classification:

C07C 253/30

Abstract:

Disclosed herein a process preparation of 2,6-dichlorobenzonitrile. A process of making high yield, high purity 2,6-dichlorobenzonitrile including the selective de-nitrochlorination of 2-chloro-6-nitrohenzonitrile by treatment of the 2-chloro-6-nitrobenzonitrile with chlorine gas.