Christopher J Larson

US Patent:

7863012, Jan 4, 2011

Filed:

Feb 17, 2004

Appl. No.:

10/780399

Inventors:

Galla Chandra Rao - Princeton Junction NJ, US
Christopher Larson - Media PA, US
Madeline Repollet - Fort Washington PA, US
Herman Rutner - Hatboro PA, US
Leon W. M. M. Terstappen - Huntingdon Valley PA, US
Shawn Mark O'Hara - Ambler PA, US
Steven Gross - Ambler PA, US

Assignee:

Veridex, LLC - Raritan NJ

International Classification:

A01N 1/02
G01N 33/574
G01N 33/553
G01N 33/00

US Classification:

435 723, 435 2, 435 721, 435 724, 435 794, 4352872, 436501, 436526, 436538, 436 10, 436175, 436177, 436813, 422 61, 422 73, 422101, 5333888, 5333897, 533413

Abstract:

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

US Patent:

20150161725, Jun 11, 2015

Filed:

Feb 20, 2015

Appl. No.:

14/627572

Inventors:

- Charlotte NC, US
David Bowman Jones - Mold, GB
John DeZervos - Morresville NC, US
Robin Griffen Cobb - Virginia Beach VI, US
Christopher A. Larson - New York NY, US

International Classification:

G06Q 40/02

Abstract:

According to some embodiments, a system includes an interface and one or more processors. The interface receives a request from a user to move a first account associated with a first enterprise to a second enterprise where the user has at least one account. The processor(s) determine first configuration settings associated with the first account. The processor(s) receive a modification request to modify or delete one or more of the first configuration settings and select second configuration settings associated with the second account based on the first configuration settings and the modification request. The processor(s) create a second account at the second enterprise and apply the second configuration settings to the second account.