Christopher J Larson

US Patent:

7863012, Jan 4, 2011

Filed:

Feb 17, 2004

Appl. No.:

10/780399

Inventors:

Galla Chandra Rao - Princeton Junction NJ, US
Christopher Larson - Media PA, US
Madeline Repollet - Fort Washington PA, US
Herman Rutner - Hatboro PA, US
Leon W. M. M. Terstappen - Huntingdon Valley PA, US
Shawn Mark O'Hara - Ambler PA, US
Steven Gross - Ambler PA, US

Assignee:

Veridex, LLC - Raritan NJ

International Classification:

A01N 1/02
G01N 33/574
G01N 33/553
G01N 33/00

US Classification:

435 723, 435 2, 435 721, 435 724, 435 794, 4352872, 436501, 436526, 436538, 436 10, 436175, 436177, 436813, 422 61, 422 73, 422101, 5333888, 5333897, 533413

Abstract:

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

US Patent:

20210321613, Oct 21, 2021

Filed:

Jun 12, 2019

Appl. No.:

17/251005

Inventors:

- Cary NC, US
Vic Prasad - Leawood KS, US
Cameron Gibb - Apex NC, US
Christopher Lynn Larson - Cary NC, US

International Classification:

A01N 43/32
C07D 341/00

Abstract:

A process for preparation of thiocyclam base and salt. A method of manufacturing N,N-dimethyl-1,2,3-trithian-5-ylainine hydrochloride is described including the steps of: providing a mixture of thiosulfuric acid S, S′[2-(dimethylamino) trimethylene] ester monosodium salt and sodium hydroxide; adding an aqueous saline solution to the mixture of thiosulfuric acid S, S′-[-(dimethylamino) trimethylene] ester monosodium salt and sodium hydroxide; separating the phases of the mixture; collecting the solids from the mixture using filtration; washing the solids with organic solvent; and drying the solids, where the dried solids are methyl-1,2,3-trithian-5-ylamine hydrochloride, and where the yield of the N,N-dimethyl-1,2,3-trithian-5-ylamine hydrochloride is increased by incorporation of a body charge of diatomaceous earth into the saline addition step, forming a mixture of the diatomaceous C earth with the composition of this step, and filtering the charged mixture through a diatomaceous earth media prior to the separation step.

US Patent:

20200157043, May 21, 2020

Filed:

Nov 15, 2019

Appl. No.:

16/685703

Inventors:

- Cary NC, US
Vic PRASAD - Leawood KS, US
Christopher Lynn LARSON - Cary NC, US
Cameron Seath GIBB - Apex NC, US
Kirit DESAI - Gujarat, IN
Ashwani GUPTA - Gujarat, IN
Girish SISODE - Gujarat, IN

Assignee:

Arysta LifeScience Inc. - Cary NC

International Classification:

C07C 253/30

Abstract:

Disclosed herein a process preparation of 2,6-dichlorobenzonitrile. A process of making high yield, high purity 2,6-dichlorobenzonitrile including the selective de-nitrochlorination of 2-chloro-6-nitrohenzonitrile by treatment of the 2-chloro-6-nitrobenzonitrile with chlorine gas.