Christopher J Larson

US Patent:

7863012, Jan 4, 2011

Filed:

Feb 17, 2004

Appl. No.:

10/780399

Inventors:

Galla Chandra Rao - Princeton Junction NJ, US
Christopher Larson - Media PA, US
Madeline Repollet - Fort Washington PA, US
Herman Rutner - Hatboro PA, US
Leon W. M. M. Terstappen - Huntingdon Valley PA, US
Shawn Mark O'Hara - Ambler PA, US
Steven Gross - Ambler PA, US

Assignee:

Veridex, LLC - Raritan NJ

International Classification:

A01N 1/02
G01N 33/574
G01N 33/553
G01N 33/00

US Classification:

435 723, 435 2, 435 721, 435 724, 435 794, 4352872, 436501, 436526, 436538, 436 10, 436175, 436177, 436813, 422 61, 422 73, 422101, 5333888, 5333897, 533413

Abstract:

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotter fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

US Patent:

8329422, Dec 11, 2012

Filed:

Nov 2, 2010

Appl. No.:

12/917630

Inventors:

Galla Chandra Rao - Princeton Jct. NJ, US
Christopher Larson - Springfield PA, US
Madeline Repollet - Fort Washington PA, US
Herman Rutner - Hatboro PA, US
Leon W. M. M. Terstappen - Amsterdam, NL
Shawn Mark O'Hara - Richboro PA, US
Steven Gross - Ambler PA, US

Assignee:

Veridex LLC - Raritan NJ

International Classification:

G01N 33/574
G01N 33/553
G01N 1/18

US Classification:

435 723, 435 721, 435 724, 435 794, 4352872, 435962, 435523, 435526, 435538, 435 64, 435164, 435175, 435177, 435813, 435824, 435825, 422 73, 422430, 5303888, 5303897, 530413

Abstract:

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CELLSPOTTER fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

US Patent:

56743726, Oct 7, 1997

Filed:

Sep 24, 1996

Appl. No.:

8/710977

Inventors:

Peter Kukanskis - Woodbury CT
Kathleen Yocis - Monroe CT
Christopher Larson - Cheshire CT

Assignee:

Mac Dermid, Incorporated - Waterbury CT

International Classification:

C25D 502

US Classification:

205118

Abstract:

A process is disclosed for the direct electroplating of a non-conductive material comprising non-conductive surfaces and metallic surfaces. The process involves contacting the non-conductive material with a compound capable of selectively forming a sacrificial layer on the metallic surfaces which sacrificial layer is substantially insoluble in alkaline or neutral media but soluble in acidic media. The foregoing step is followed by deposition of carbon onto the surfaces followed by contact with an acidic solution and subsequent electroplating.

US Patent:

20150240660, Aug 27, 2015

Filed:

Mar 15, 2013

Appl. No.:

14/427679

Inventors:

- Hartford CT, US
Russell B. Witlicki - Wethersfield CT, US
Christopher J. Larson - Newfield ME, US
Robert C. Stutz - Dobbs Ferry NY, US
Eric Charles Mundell - South Berwick ME, US
Marc J. Muldoon - Marlborough CT, US

International Classification:

F01D 25/12
F02C 7/06
F01D 25/24
F01D 25/14
F01D 25/16

Abstract:

A seal support and duct assembly of a gas turbine engine includes a seal support housing disposed about a central axis, a duct housing attached to the seal support housing, the duct housing and the seal support housing defining the seal support and duct assembly, an outer annular cavity, an inlet that supplies the outer annular cavity with cooling buffer air, an inner annular cavity disposed radially inward of the outer annular cavity, a first plurality of outlets that provide the cooling buffer air from the outer annular cavity to the inner annular cavity, and a second plurality of outlets that provide the cooling buffer air from the inner annular cavity to an area surrounding a bearing compartment.

US Patent:

20140119887, May 1, 2014

Filed:

Nov 1, 2012

Appl. No.:

13/666591

Inventors:

United Technologies Corporation - , US
Fungayi Mutsengi - Bloomfield CT, US
Ernest Boratgis - South Windsor CT, US
Santosh Ranganath - Glastonbury CT, US
Christopher J. Larson - Newfield ME, US
M. Rifat Ullah - South Windsor CT, US

Assignee:

UNITED TECHNOLOGIES CORPORATION - Hartford CT

International Classification:

F01D 11/00

US Classification:

415110, 298892

Abstract:

A rotational component for a gas turbine engine includes at least one passage with a semi-spherical end.