Christopher William Mathes

US Patent:

20020098575, Jul 25, 2002

Filed:

Jan 25, 2001

Appl. No.:

09/769609

Inventors:

Christopher Mathes - Foster City CA, US
Gregory Hamersly - Atascadero CA, US

International Classification:

C12M003/00

US Classification:

435/287300, 435/286200, 435/029000, 435/288700

Abstract:

An automated mechanism for guiding a microelectrode toward an oocyte placed in a perfusion chamber consists of a movable guide tube holding the electrode and a fixed guide collar in fixed relation to the target oocyte. Because the guide tube and guide collar are independently mounted, the alignment of the tip of the microelectrode is effected by its placement within the precisely aligned guide collar, irrespective of any fine misalignment of the guide tube. Accordingly, a change of microelectrode in the guide tube does not affect its final alignment toward the oocyte so long as the calibration of the guide collar is not disturbed, thereby providing a mechanism for maintaining the alignment of different microelectrodes successively mounted in the system without requiring recalibration.

US Patent:

20130334062, Dec 19, 2013

Filed:

Feb 29, 2012

Appl. No.:

14/002671

Inventors:

Jonatan Kutchinsky - Ballerup, DK
Nicholas Byrne - Antioch CA, US
Christopher Mathes - Annandale NJ, US
Jens Henneke - Hvalso, DK

Assignee:

SOPHION BIOSCIENCE A/S - Ballerup

International Classification:

G01N 27/28

US Classification:

205778, 422525, 20440302

Abstract:

A handheld device for analysis of electro-physiological properties of a cellular membrane ion channel in an ion channel containing lipid cellular membrane comprises a handheld body with a pump and an electronic controller, and a disposable pipette tip comprising a pathway for fluid, said pathway connecting an open end of the pipette tip to an analysis substrate comprised in the pipette tip. The substrate is adapted to transmit an electrical current through the ion channel in said ion channel-containing lipid cellular membrane, when said lipid cellular membrane is held at a predetermined site of the substrate, e.g. for patch clamp analysis. The handheld body and the disposable pipette tip are configured to releasably attach the pipette tip to the body, to provide a hydraulic connection between the pump of the handheld body and said pathway, and to provide an electric connection between the electronic controller and at least one of said electrodes of the substrate. The electronic controller of the handheld body is configured to operate the assembled device for micfofluidic analysis of aspirated fluid.

Address:

3256 Aleah Ct, Cuyahoga Falls, OH 44223

Phone:

7325861073

VIN:

WVWNP7ANXBE712087

Make:

VOLKSWAGEN

Model:

CC

Year:

2011