Christopher Thomas O'Brien

US Patent:

20120029211, Feb 2, 2012

Filed:

Apr 6, 2010

Appl. No.:

13/263224

Inventors:

Christopher J. O'Brien - Arlington TX, US

International Classification:

C07D 333/24
C07C 1/20
C07C 17/272
C07C 67/40
C07C 67/44
C07C 253/30

US Classification:

549 74, 560104, 558401, 549 79, 560 20, 558430, 558462, 560211, 560 8, 570144, 585640

Abstract:

A catalytic Wittig method utilizing a phosphine including the steps of providing a phosphine oxide precatalyst and reducing the phosphine oxide precatalyst to produce the phosphine; forming a phosphonium ylide precursor from the phosphine and a reactant; generating a phosphonium ylide from the phosphonium ylide precursor; reacting the phosphonium ylide precursor with the aldehyde, ketone, or ester to form the olefin and the phosphine oxide which then reenters the cycle. The invention is also directed to a Mitsunobu reaction catalytic in phosphine.

US Patent:

20160228611, Aug 11, 2016

Filed:

Sep 15, 2015

Appl. No.:

14/854504

Inventors:

- Washington DC, US
Christopher M. O'Brien - Washington DC, US
Lijie Grace Zhang - Arlington VA, US

International Classification:

A61L 27/48
A61L 27/18
A61L 27/54
A61L 27/12

Abstract:

The invention describes methods for producing a biphasic nanocomposite scaffold comprising custom polymer-based core-shelled nanospheres by the physical and chemical attachment of two disparate polymeric materials whose composition can be readily modified with tissue-specific nanomaterials and products created using such methods. The custom nanospheres are constructed via co-axial wet electrospraying and can be employed to deliver compounds to the polymeric materials.