Christopher C Reinhardt

US Patent:

20030059368, Mar 27, 2003

Filed:

Jan 30, 2002

Appl. No.:

10/060652

Inventors:

Ernest Groman - Brookline MA, US
Christopher Reinhardt - Worcester MA, US

International Classification:

A61M036/14

US Classification:

424/001110

Abstract:

Stable isotope labeling and neutron activation to measure biological functions are provided, as are the use and method of adding a chemical monitor to correct for neutron flux to sample vials prior to the addition of sample is presented, and the use of stable isotopes as a chemical bar code for vials and other items. Methods are provided also for measuring glomerular filtration rate and glomerular sieving function in a subject, and for measuring other physiological functions.

US Patent:

20060014938, Jan 19, 2006

Filed:

Apr 6, 2005

Appl. No.:

11/099832

Inventors:

Ernest Groman - Brookline MA, US
Christopher Reinhardt - Worcester MA, US
Dennis Vaccaro - Wellesley MA, US

International Classification:

C08J 3/02

US Classification:

534015000, 516105000

Abstract:

A stable aqueous colloidal lanthanide oxide is provided, which can be sterilized by filtration, gamma irradiation, and autoclaving. The stable colloid is also provided having one or more polymers associated to confer biological properties. Compositions, methods of making the compositions, and methods of using the compositions are provided as agents for enhanced magnetic resonance imaging, enhanced computer tomography, cell labeling and cell-tracking in vivo, neutron capture therapy, and brachytherapy, the agents comprising lanthanide oxides as stable colloidal suspensions in water based solvents.

US Patent:

20060067881, Mar 30, 2006

Filed:

Oct 12, 2005

Appl. No.:

11/248541

Inventors:

Ernest Groman - Brookline MA, US
Christopher Reinhardt - Worcester MA, US

International Classification:

A61K 51/00
A61K 49/00
G06F 19/00

US Classification:

424001110, 424009200, 702019000

Abstract:

Stable isotope labeling and neutron activation to measure biological functions are provided, as are the use and method of adding a chemical monitor to correct for neutron flux to sample vials prior to the addition of sample is presented, and the use of stable isotopes as a chemical bar code for vials and other items. Methods are provided also for measuring glomerular filtration rate and glomerular sieving function in a subject, and for measuring other physiological functions.

US Patent:

20070166774, Jul 19, 2007

Filed:

Dec 5, 2006

Appl. No.:

11/633909

Inventors:

Ernest V. Groman - Brookline MA, US
Christopher P. Reinhardt - Worcester MA, US
Dennis E. Vaccaro - Wellesley MA, US

International Classification:

G01N 33/53
C07K 16/18

US Classification:

435 792, 5303881

Abstract:

Compositions, methods, and functional immunoassays for measuring functioning of organs, receptors, and biological processes in a subject are provided. Functional immunoassay combines pharmacokinetics of xenobiotics after administering one or more of the compositions to a subject by quantifying the xenobiotic in samples taken from the subject. The method provides a xenobiotic that is processed principally by a single organ system with minimal metabolism and involves administering the xenobiotic to the subject, measuring its concentration in samples of biological material obtained over time, calculating a kinetic parameter that describes change in concentration over time, and associating this parameter with the functioning of the target organ. Functional immunoassay is used for measuring, for example, kidney, brain, lung, cardiovascular, gastrointestinal, and immune system function; progression of cancer and infectious disease; and diabetes and inflammatory disease status. Xenobiotics include, for example, drugs, ligands, hormone analogs, substrates, polysaccharides, and nucleic acids and respective analogs.