Christopher E Rhodes

US Patent:

20050042280, Feb 24, 2005

Filed:

Dec 26, 2002

Appl. No.:

10/498801

Inventors:

Tracey Rogers - Boyds MD, US
Jeffrey Williamson - Greenville NC, US
Christopher Rhodes - San Diego CA, US

International Classification:

A61K031/66
A61K009/20

US Classification:

424464000, 514129000, 514018000, 514474000, 514566000, 514574000

Abstract:

The present invention is directed to aqueous based formulations of water-soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water-soluble prodrug of propofol and an effective amount of an antioxidant. In one embodiment, the formulation also contains a tonicity modifier. The formulations are particularly useful as intravenous injections. The formulations preferably are buffered to a pH suitable for minimizing degradation of the prodrug during storage. Advantageously, the formulations can be prepared without the use of harmful co-solvents or surfactants, and are stable at room temperature over extended periods of time.