Christopher T Seto

US Patent:

20030120073, Jun 26, 2003

Filed:

Apr 5, 2002

Appl. No.:

10/117699

Inventors:

Christopher Seto - Barrington RI, US

International Classification:

C07F007/02
C07D213/63
C07D213/72
C07D213/70

US Classification:

546/014000, 546/335000, 546/290000, 546/304000, 546/314000, 552/007000, 558/414000, 562/430000, 560/358000, 556/437000

Abstract:

Protein tyrosine phosphatases (PTPs) are implicated in a number of disease processes, including autoimmune diseases, glucose intolerance, diabetes, obesity and certain types of proliferative diseases such as cancer and psoriasis. The present invention discloses novel -ketocarboxylic acid inhibitors of PTPs, methods for synthesizing said inhibitors, and methods for using pharmaceutical compositions of the inhibitors to treat PTP-mediated disorders, diseases or dysfunctions. The compositions described herein can also be used as diagnostic and screening tools to elucidate complex signal transduction pathways involving PTPs or to identify PTP-mediated disease states.