Christopher Chad Shelton

US Patent:

20110143954, Jun 16, 2011

Filed:

May 7, 2010

Appl. No.:

12/776141

Inventors:

Christopher Shelton - Alexandria VA, US
Yuan Tian - New York NY, US
Yueming Li - New York NY, US

Assignee:

Memorial Sloan-Kettering Cancer Center - New York NY

International Classification:

G01N 33/573
C12Q 1/37
C12P 21/06
C12N 9/99
C12N 5/02
C40B 30/04
C07K 14/47
C07K 7/06
C07H 21/04

US Classification:

506009000, 435007400, 435023000, 435069100, 435184000, 435375000, 530324000, 530328000, 530329000, 536023500

Abstract:

Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase.

US Patent:

20110306605, Dec 15, 2011

Filed:

Dec 21, 2009

Appl. No.:

13/140791

Inventors:

Lei Zhu - Schenectady NY, US
Hakim Djaballah - Scarsdale NY, US
Yueming Li - New york NY, US
Christopher Chad Shelton - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61K 31/5513
A61P 35/00
A61P 29/00
A61K 31/381

US Classification:

514221, 514445

Abstract:

Compounds including those of the Formula Iwhere X, R, Rand subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compounds for treating or preventing neurodegenerative diseases, such as, for instance, Alzheimer's disease.

US Patent:

20150133493, May 14, 2015

Filed:

Jul 3, 2014

Appl. No.:

14/323438

Inventors:

- New York NY, US
Hakim Djaballah - Scarsdale NY, US
Yueming Li - New York NY, US
Christopher Chad Shelton - New York NY, US

International Classification:

C07D 493/04
C07D 335/06
C07D 215/20
C07D 311/56

US Classification:

514312, 549400, 514457, 549 23, 514432, 549384, 546155

Abstract:

Compounds including those of the Formula Iwhere X, R, Rand subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compounds for treating or preventing neurodegenerative diseases, such as, for instance, Alzheimer's disease.