Christopher W Shelton

US Patent:

20110143954, Jun 16, 2011

Filed:

May 7, 2010

Appl. No.:

12/776141

Inventors:

Christopher Shelton - Alexandria VA, US
Yuan Tian - New York NY, US
Yueming Li - New York NY, US

Assignee:

Memorial Sloan-Kettering Cancer Center - New York NY

International Classification:

G01N 33/573
C12Q 1/37
C12P 21/06
C12N 9/99
C12N 5/02
C40B 30/04
C07K 14/47
C07K 7/06
C07H 21/04

US Classification:

506009000, 435007400, 435023000, 435069100, 435184000, 435375000, 530324000, 530328000, 530329000, 536023500

Abstract:

Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase.

US Patent:

20210405256, Dec 30, 2021

Filed:

Jun 22, 2021

Appl. No.:

17/354686

Inventors:

- Raleigh NC, US
Christopher Shelton - Cary NC, US

International Classification:

G02B 1/00
G02B 5/20

Abstract:

A device includes a substrate having a pattern of surface features on a surface thereof, and a layer including a material having an Epsilon-Near-Zero (ENZ) condition for a wavelength range. The layer extends on the surface of the substrate and along the pattern of surface features. Related devices and fabrication methods are also discussed.

US Patent:

20180350922, Dec 6, 2018

Filed:

May 24, 2018

Appl. No.:

15/988883

Inventors:

- Raleigh NC, US
Christopher Shelton - Raleigh NC, US
Jon-Paul Maria - Raleigh NC, US
Kyle Patrick Kelley - Lake Lure NC, US
Evan Lars Runnerstrom - Durham NC, US

International Classification:

H01L 29/267
C23C 14/08
C23C 14/35
H01L 21/02
H01L 21/477

Abstract:

A method of forming a metal oxide includes providing a reactive deposition atmosphere having an oxygen concentration of greater than about 20 percent in a chamber including a substrate therein. A pulsed DC signal is applied to a sputtering target comprising a metal, to sputter metal particles therefrom. A doping element may be supplied from a doping source (such as an alloyed metal target) in the reaction chamber. An electrically conductive metal oxide film comprising an oxide of the metal is deposited on the substrate responsive to a reaction between the metal particles and the reactive deposition atmosphere. Related devices are also discussed.

US Patent:

20180013031, Jan 11, 2018

Filed:

Jul 7, 2017

Appl. No.:

15/644216

Inventors:

- Raleigh NC, US
Jon-Paul Maria - Raleigh NC, US
Christopher Shelton - Raleigh NC, US

International Classification:

H01L 31/112
G02B 5/00
G01J 1/44
H01L 31/0296
G01J 1/04

Abstract:

Polaritonic hot electron infrared photodetector that detect infrared radiation. In one implementation, the polaritonic hot electron infrared photodetector includes a first contact layer, a second contact layer, a first dielectric layer, a second dielectric layer, and a conductor layer. The first dielectric layer is coupled between the first contact layer and the second contact layer. The second dielectric layer is coupled between the first dielectric layer and the second contact layer. The conductor layer is coupled between the first dielectric layer and the second dielectric layer. Infrared radiation incident upon the conductor layer is operable to create hot carriers that are injected from a conduction band of the conductor layer to a conduction band of the second contact layer.