The present invention provides for systems and methods that utilize automated and integratable workstations for identifying chemicals having useful activity. The present invention is also directed to chemical entities and information (e. g. , chemical or biological activities of chemicals) generated or discovered by operation of workstations of the present invention. The present invention includes automated workstations that are programmably controlled to minimize processing times at each workstation and that can be integrated to minimize the processing time of the liquid samples from the start to finish of the process.
Systems And Methods For Rapidly Identifying Useful Chemicals In Liquid Samples
Substances having useful pharmacological properties are identified by candidate screeners and screening methods. The substances may be incorporated into medicaments. The substances may have modulating activity with respect to pre-defined molecular targets.
Systems And Methods For Rapidly Identifying Useful Chemicals In Liquid Samples
Chari Stylli - San Diego CA Samuel S. Beckey - San Diego CA Christopher Bentley Shumate - La Jolla CA Peter J. Coassin - Encinitas CA
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
G06F 700
US Classification:
700218, 700213, 422 65, 422 67, 436 47, 436 48
Abstract:
The present invention provides for systems and methods that utilize automated and integratable workstations for identifying chemicals having useful activity. The present invention is also directed to chemical entities and information (e. g. , chemical or biological activities of chemicals) generated or discovered by operation of workstations of the present invention. The present invention includes automated workstations that are programmably controlled to minimize processing times at each workstation and that can be integrated to minimize the processing time of the liquid samples from the start to finish of the process.
Methods For Rapidly Identifying Useful Chemicals In Liquid Sample
Chari Stylli - San Diego CA Samuel S. Beckey - San Diego CA Christopher Bentley Shumate - La Jolla CA Peter J. Coassin - Encinitas CA
Assignee:
Vertex Pharmaceuticals, Inc. - San Diego CA
International Classification:
G01N 3502
US Classification:
422 63, 422 65, 422104, 414277, 1983472, 198348
Abstract:
A high throughput chemical screening method uses methods of concurrent transport and/or processing to increase throughput. A screener may concurrently retrieve chemicals from an addressable chemical storage module and deliver chemicals to a liquid handling module. The screener may also use one transport lane for moving chemicals away from a storage module, and a second transport lane for moving chemicals toward the storage module.
A microplate lid having a substantially flat, generally rectangular top with first and second pairs of opposite sides. A flange depends from the top of the first and second pairs of sides, the flange bearings at least one recess area along each side of the first pair of sides, the recessed area extended into the top.
Apparatus and methods are provided herein for conducting processes, such as biological and biochemical processes, that provide a fluid environment in which such processes can be conducted in the presence of a substantially laminar flow of the fluid through the environment. Elements of the processes, such biological or biochemical entities, can be maintained in the substantially laminar flow of fluid with minimal disruption during the processes.
Christopher Shumate - La Jolla CA, US Peter Coassin - Encinitas CA, US
International Classification:
B01L003/00
US Classification:
422099000
Abstract:
A microplate lid having a substantially flat, generally rectangular top with first and second pairs of opposite sides. A flange depends from the top of the first and second pairs of sides, the flange bearing at least one recess area along each side of the first pair of sides, the recessed area extending into the top.
A high throughput chemical handling system includes a chemical storage module, a transport module, and one or more liquid handling modules. The transport module may implement parallel chemical transport, and the system may include a plurality of asynchronously operable liquid handling modules coupled to the parallel transport module.