Christopher L Simms

US Patent:

20080057571, Mar 6, 2008

Filed:

Apr 27, 2007

Appl. No.:

11/741390

Inventors:

Elizabeth Loboa - Raleigh NC, US
Nicholas Jardine - Cary NC, US
Jennifer Jassawalla - Presto PA, US
Jillian Rouse - Clinton NC, US
Christopher Simms - Anchorage AK, US
Jeffrey SooHoo - Apex NC, US
J. Stancil - Lillington NC, US

International Classification:

C12M 3/00

US Classification:

435293100

Abstract:

A system for exposing a cell culture to a fluid shear force imparted by a fluid flow is provided. Specifically, various embodiments of the present invention provide flow chambers defining channels for retaining a cell culture in the fluid flow wherein the flow chambers may be removably disposed within a bioreactor system such that the flow chambers may be removed and/or replaced without disturbing the cell cultures retained therein or disposed elsewhere within the bioreactor system. The flow chambers are composed of a transparent material such that a user of the system may observe the development of the cell culture retained within the chamber as the cell culture is imposed to a fluid shear stress imparted by the fluid flow.