Christopher I Ward

Address:

17704 Wormer St, Detroit, MI 48219

Phone:

5183708739

VIN:

1G6DP577X70138753

Make:

CADILLAC

Model:

CTS

Year:

2007

US Patent:

7820963, Oct 26, 2010

Filed:

Aug 5, 2008

Appl. No.:

12/186381

Inventors:

Christopher William Ward Beecher - Ann Arbor MI, US

Assignee:

Metabolic Alayses, Inc. - Chapel Hill NC

International Classification:

B01D 59/44

US Classification:

250282, 250281, 250288, 435 6, 435 41, 435 42, 436 15, 436 19, 436 56

Abstract:

A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control sample is grown with a nutrient having an isotope of a first atom, whereas the experimental sample is grown with a nutrient having a second isotope of the first atom. The experimental sample is grown with a stressing agent and regimen. The samples are admixed, and the formed composite is mass spectroscopically assayed for analyte peaks. The ratio of first isotope to second isotope is determined for the peaks, as is a sample median isotopic ratio. The ratio for assayed analyte peaks is compared with the median ratio. An analyte whose isotopic ratio significantly deviates from the median ratio is an analyte affected by the stressing agent.

US Patent:

7820964, Oct 26, 2010

Filed:

Aug 5, 2008

Appl. No.:

12/186395

Inventors:

Christopher William Ward Beecher - Ann Arbor MI, US

Assignee:

Metabolic Analyses, Inc - Chapel Hill NC

International Classification:

B01D 59/44
H01J 49/00

US Classification:

250282, 250281, 250288, 506 12, 2042287

Abstract:

A composition adapted for mass spectral analysis is disclosed as are methods of its use in mass spectral analyses. A contemplated composition contains a mass spectrally-determinable amount of each of (i) at least one analyte to be assayed and (ii) a standard compound. Each of the molecules of the standard compound contains one or the other of a pair of two stable isotopes of the same element that differ in molecular weight by at least two atomic mass units. Those two isotopes are present in the molecules of the standard compound in a predetermined ratio that is other than the naturally occurring ratio of those isotopes.

US Patent:

8168945, May 1, 2012

Filed:

Oct 25, 2010

Appl. No.:

12/911538

Inventors:

Christopher William Ward Beecher - Ann Arbor MI, US

Assignee:

Metabolic Analyses, Inc. - Chapel Hill NC

International Classification:

B01D 59/44
H01J 49/00

US Classification:

250282, 250281, 250288, 435 6, 435 41, 435 42, 436 15, 436 19, 436 56

Abstract:

A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control sample is grown with a nutrient having an isotope of a first atom, whereas the experimental sample is grown with a nutrient having a second isotope of the first atom. The experimental sample is grown with a stressing agent and regimen. The samples are admixed, and the formed composite is mass spectroscopically assayed for analyte peaks. The ratio of first isotope to second isotope is determined for the peaks, as is a sample median isotopic ratio. The ratio for assayed analyte peaks is compared with the median ratio. An analyte whose isotopic ratio significantly deviates from the median ratio is an analyte affected by the stressing agent.

US Patent:

8536520, Sep 17, 2013

Filed:

Oct 25, 2010

Appl. No.:

12/911524

Inventors:

Christopher William Ward Beecher - Ann Arbor MI, US

Assignee:

IROA Technologies LLC - Ann Arbor MI

International Classification:

B01D 59/44

US Classification:

250282, 250281, 250288, 435 6, 435 41, 435 42, 435 15, 436 15, 436 19, 436 56, 514 2, 514 44 A

Abstract:

A method for identifying a biological analyte that is affected by a stressor is disclosed in which two substantially identical biological samples are provided, with a first sample being a control sample and a second sample being an experimental sample. The control sample is grown with a nutrient having an isotope of a first atom, whereas the experimental sample is grown with a nutrient having a second isotope of the first atom. The experimental sample is grown with a stressing agent and regimen. The samples are admixed, and the formed composite is mass spectroscopically assayed for analyte peaks. The ratio of first isotope to second isotope is determined for the peaks, as is a sample median isotopic ratio. The ratio for assayed analyte peaks is compared with the median ratio. An analyte whose isotopic ratio significantly deviates from the median ratio is an analyte affected by the stressing agent.

US Patent:

20090124518, May 14, 2009

Filed:

Oct 2, 2008

Appl. No.:

12/244555

Inventors:

Christopher William Ward Beecher - Ann Arbor MI, US

International Classification:

C40B 40/18
B01D 59/44

US Classification:

506 22, 250282

Abstract:

A method for assaying phenotypic similarity or dissimilarity between organisms is disclosed in which a composite sample of admixed first and second samples is provided. The first, standard sample contains average concentrations of compounds of molecular mass less than about 1000 AMU present in the organism species. The second, assay sample contains compounds of having a similar molecular mass present in the organism whose phenotype is to be assayed. The constituents of both samples are (i) in a liquid medium and (ii) each compound of a sample has the same, first and second respective amounts of first and second stable isotopes of a first atom. The composite sample is mass spectroscopically analyzed for analytes, with the ratio of first to second isotope being determined for each analyte, along with a composite sample median ratio. The ratios for each analyte are compared to the median, with outlying ratios indicating dissimilarity.