Christopher F Werner

US Patent:

7626041, Dec 1, 2009

Filed:

Jun 25, 2007

Appl. No.:

11/767573

Inventors:

Christopher S. Brook - King of Prussia PA, US
Wei Chen - Woodbury MN, US
Philip C. Dell'orco - King of Prussia PA, US
Lee M. Katrincic - King of Prussia PA, US
Ann Marie Louvet - King of Prussia PA, US
Choon K. Oh - Oaks PA, US
Paul G. Spoors - King of Prussia PA, US
Christopher Werner - King of Prussia PA, US

Assignee:

SmithKline Beecham (Cork) Ltd - County Cork

International Classification:

C07D 209/82

US Classification:

548444

Abstract:

The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i. e. , dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc. ), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

US Patent:

7750036, Jul 6, 2010

Filed:

Nov 24, 2004

Appl. No.:

10/997230

Inventors:

Christopher S. Brook - King of Prussia PA, US
Pingyun Y. Chen - Indianapolis IN, US
Wei Chen - Woodbury MN, US
Qunying Dai - King of Prussia PA, US
Philip C. Dell'Orco - King of Prussia PA, US
Clifford S. Labaw - King of Prussia PA, US
Ann Marie Diederich - King of Prussia PA, US
Choon K. Oh - Collegeville PA, US
Claire Hisler - Meyzieu, FR
David H. Igo - Research Triangle Park NC, US
Lee M. Katrincic - King of Prussia PA, US
Li-Jen Ping - King of Prussia PA, US
Paul G. Spoors - King of Prussia PA, US
Jun Wang - King of Prussia PA, US
Christopher Werner - King of Prussia PA, US

Assignee:

SB Pharmco Puerto Rico Inc. - Hato Rey PR

International Classification:

A61K 31/403
C07D 209/82

US Classification:

514411, 548440

Abstract:

The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i. e. , which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc. ) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

US Patent:

7759384, Jul 20, 2010

Filed:

Jun 25, 2007

Appl. No.:

11/767581

Inventors:

Christopher S. Brook - King of Prussia PA, US
Wei Chen - Woodbury MN, US
Philip C. Dell'orco - King of Prussia PA, US
Lee M. Katrincic - King of Prussia PA, US
Ann Marie Louvet - King of Prussia PA, US
Choon K. Oh - Oaks PA, US
Paul G. Spoors - King of Prussia PA, US
Christopher Werner - King of Prussia PA, US

Assignee:

SmithKline Beecham (Cork) Limited - Currabinny, Carrigaline, County Cork

International Classification:

A61K 31/40
C07D 209/82

US Classification:

514411, 548444

Abstract:

The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i. e. , dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc. ), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

US Patent:

7893100, Feb 22, 2011

Filed:

Jun 25, 2007

Appl. No.:

11/767578

Inventors:

Christopher S. Brook - King of Prussia PA, US
Wei Chen - Woodbury MN, US
Philip C. Dell'Orco - King Of Prussia PA, US
Lee M. Katrincic - King Of Prussia PA, US
Ann Marie Louvet - King Of Prussia PA, US
Choon K. Oh - Oaks PA, US
Paul G. Spoors - King Of Prussia PA, US
Christopher Werner - King of Prussia PA, US

Assignee:

SB Pharmco Puerto Rico Inc. - Hato Rey PR

International Classification:

C07D 209/88
A61K 31/403

US Classification:

514411, 548444

Abstract:

The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i. e. , dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc. ), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

US Patent:

7902378, Mar 8, 2011

Filed:

Jun 25, 2007

Appl. No.:

11/767586

Inventors:

Christopher S. Brook - King of Prussia PA, US
Wei Chen - Woodbury MN, US
Philip C. Dell'Orco - King of Prussia PA, US
Lee M. Katrincic - King of Prussia PA, US
Ann Marie Louvet - King of Prussia PA, US
Choon K. Oh - Oaks PA, US
Paul G. Spoors - King of Prussia PA, US
Christopher Werner - King of Prussia PA, US

Assignee:

SmithKline Beecham (Cork) Limited - Cork

International Classification:

C07D 209/82

US Classification:

548444

Abstract:

The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i. e. , dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc. ), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

US Patent:

20050240027, Oct 27, 2005

Filed:

Jun 27, 2003

Appl. No.:

10/518654

Inventors:

Christopher Brook - King of Prussia PA, US
Wei Chen - Woodbury MN, US
Philip Dell'Orco - King of Prussia PA, US
Lee Katrincic - King of Prussia PA, US
Ann Louvet - King of Prussia PA, US
Choon Oh - Oaks PA, US
Paul Spoors - King of Prussia PA, US
Christopher Werner - King of Prussia PA, US

International Classification:

A61K031/403
C07D209/82

US Classification:

548444000, 514411000

Abstract:

The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

US Patent:

20070259940, Nov 8, 2007

Filed:

Jun 25, 2007

Appl. No.:

11/767566

Inventors:

Christopher BROOK - King of Prussia PA, US
Wei Chen - Woodbury MN, US
Philip Dell'Orco - King Of Prussia PA, US
Lee Katrincic - King Of Prussia PA, US
Ann Louvet - King Of Prussia PA, US
Choon Oh - Oaks PA, US
Paul Spoors - King Of Prussia PA, US
Christopher Werner - King of Prussia PA, US

International Classification:

A61K 31/403
A61P 9/04
C07D 209/82

US Classification:

514411000, 548444000

Abstract:

The present invention relates to carvedilol phosphate salts, which include novel crystalline forms of carvedilol dihydrogen phosphate (i.e., dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate,etc.), and/or solvates thereof, compositions containing the aforementioned salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.

US Patent:

20090159841, Jun 25, 2009

Filed:

Jun 9, 2005

Appl. No.:

11/569897

Inventors:

Ann Marie Elderidge - King of Prussia PA, US
Christopher Werner - King of Prussia PA, US

Assignee:

SMITHKLINE BEECHAM CORPORATION - Philadelphia PA

International Classification:

C09K 3/00
C07D 301/32
C07D 405/02
C07D 301/19

US Classification:

25218212, 549541, 548467, 549529

Abstract:

A process to recover optically active epoxy alcohols from asymmetric epoxidation reaction mixtures such as those produced using the Sharpless method of epoxidation of allylic alcohols. The process includes adding a reducing agent to reduce an organic hydroperoxide in the asymmetric epoxidation reaction product to a corresponding alcohol to form a reduced epoxidation reaction mixture; adding the reduced reaction product to a film evaporation unit to form a residue fraction and an optically active epoxy alcohol distillate fraction; and distilling the optically active epoxy alcohol distillate fraction to purify the optically active epoxy alcohol.