Claire F Fraser

US Patent:

6380369, Apr 30, 2002

Filed:

Aug 23, 1994

Appl. No.:

08/294312

Inventors:

Mark D. Adams - North Potomac MD
Robert D. Fleischmann - Gaithersburg MD
Claire M. Fraser - Potomac MD
Rebecca A. Fuldner - Barnesville MD
Ewen F. Kirkness - Olney MD
William A. Haseltine - Washington DC
Craig A. Rosen - Laytonsville MD
Steve Ruben - Olney MD
Ying-Fei Wei - Darnestown MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07H 2102

US Classification:

536 231, 435 6

Abstract:

The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins which may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.

US Patent:

6416984, Jul 9, 2002

Filed:

Jun 6, 1995

Appl. No.:

08/468024

Inventors:

William A. Haseltine - Washington DC
Steven M. Ruben - Olney MD
Ying-Fei Wei - Darnestown MD
Mark D. Adams - North Potomac MD
Robert D. Fleischmann - Gaithersburg MD
Claire M. Fraser - Potomac MD
Rebecca A. Fuldner - Barnesville MD
Ewen F. Kirkness - Olney MD
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 900

US Classification:

435183, 435195

Abstract:

The invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.

US Patent:

6482606, Nov 19, 2002

Filed:

Jan 27, 1994

Appl. No.:

08/187757

Inventors:

Mark D. Adams - North Potomac MD
Robert D. Fleischmann - Washington DC
Claire M. Fraser - Queenstown MD
Rebecca A. Fuldner - Barnesville MD
Ewen F. Kirkness - Washington DC
William A. Haseltine - Washington DC
Craig A. Rosen - Laytonsville MD
Steve Ruben - Olney MD
Ying-Fei Wei - Darnestown MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12P 2102

US Classification:

435 691, 435 711, 435 712, 435243, 4352523, 4353201, 435325, 435410, 536 231, 536 232, 536 235

Abstract:

The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.

US Patent:

6537773, Mar 25, 2003

Filed:

Oct 19, 1995

Appl. No.:

08/545528

Inventors:

Claire M. Fraser - Potomac MD
Mark D. Adams - N. Potomac MD
Jeannine D. Gocayne - Silver Spring MD
Hamilton O. Smith - Towson MD
J. Craig Venter - Potomac MD
Owen White - Gaithersburg MD

Assignee:

The Institute for Genomic Research - Rockville MD
Johns Hopkins University - Baltimore MD
The University of North Carolina at Chapel Hill - Chapel Hill NC

International Classification:

C12Q 168

US Classification:

435 691, 536 237, 536 2432, 4352523, 4353201

Abstract:

The present invention provides the nucleotide sequence of the entire genome of , SEQ ID NO:1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies protein encoding fragments of the genome, and identifies, by position relative to two (2) genes known to flank the origin of replication, any regulatory elements which modulate the expression of the protein encoding fragments of the genome.

US Patent:

6610477, Aug 26, 2003

Filed:

Jun 6, 1995

Appl. No.:

08/465679

Inventors:

William A. Haseltine - Washington DC
Steven M. Ruben - Brookeville MD
Ying-Fei Wei - Berkeley CA
Mark D. Adams - Rockville MD
Robert D. Fleischmann - Gaithersburg MD
Claire M. Fraser - Potomac MD
Rebecca A. Fuldner - Barnesville MD
Ewen F. Kirkness - Olney MD
Craig A. Rosen - Laytonsville MD
Bert Vogelstein - Baltimore MD
Kenneth W. Kinzler - Bel Air MD
Nicholas C. Nicolaides - Boothwyn PA
Nickolas Papadopoulos - Brookline MA

Assignee:

Human Genome Sciences, Inc. - Rockville MD
The Johns Hopkins University - Baltimore MD

International Classification:

C12Q 168

US Classification:

435 6, 436 94

Abstract:

The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins and a procedure for producing such proteins by recombinant techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for therapeutic and diagnostic treatments of a hereditary susceptibility to cancer.

US Patent:

6620619, Sep 16, 2003

Filed:

Mar 16, 1994

Appl. No.:

08/210143

Inventors:

William A. Haseltine - Washington DC
Steven Ruben - Olney MD
Ying-Fei Wei - Darnestown MD
Mark D. Adams - North Potomac MD
Robert D. Fleischmann - Washington DC
Claire M. Fraser - Queenstown MD
Craig A. Rosen - Laytonsville MD
Rebecca A. Fuldner - Barnesville MD
Ewen F. Kirkness - Washington DC

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

G01N 3306

US Classification:

436 231

Abstract:

The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.

US Patent:

6635252, Oct 21, 2003

Filed:

Jun 20, 2001

Appl. No.:

09/883985

Inventors:

Guo-Liang Yu - Darnestown MD
Craig A. Rosen - Laytonsville MD
Claire M. Fraser - Queenstown MD
Jeannine D. Gocayne - Silver Spring MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 1600

US Classification:

4241461, 4241411, 5303871, 5303873, 53038826, 5303891

Abstract:

Polynucleotides which encode the polypeptide SOD-4, as well as such polypeptides, and antibodies against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cerebral ischaemia, ulcers, inflammation, arrhythmia, oedema and paraquat intoxication as well as rheumatoid arthritis, osteoarthritis and radiation injury.

US Patent:

7087410, Aug 8, 2006

Filed:

Jan 14, 2002

Appl. No.:

10/466196

Inventors:

Nils Kåre Birkeland - N-5162 Laksevåg, NO
Ingvar Eidhammer - N-5261 Indre Arna, NO
Inge Jonassen - N-5224 Nesttun, NO
Harald B. Jensen - N-5105 Eidsvåg, NO
Torleiv Lien - N-5035 Bergen, NO
Johan R. Lillehaug - N-5052 Bergen, NO
Ivar Lossius - N-5035 Bergen, NO
Jonathan A. Eisen - Gaithersburg MD, US
Claire M. Fraser - Potomac MD, US
A. Scott Durkin - Germantown MD, US
Steven L. Salzberg - Gaithersburg MD, US

International Classification:

C12P 21/04

US Classification:

435 697, 536 237, 536 241, 536 242, 4353201, 435 691, 435243, 4352523, 530350, 4242341, 4241921, 4241931

Abstract:

The present invention relates to an expression system for the expression of proteins and peptides in a methanotrophic bacterium, preferable the. Further, the invention relates to the exportation and display of said peptides and proteins on the surface of said bacteria. The invention also describes a method for the production of a desired protein in the.