Claire E Mcgrath

US Patent:

20030170278, Sep 11, 2003

Filed:

Mar 11, 2002

Appl. No.:

10/095503

Inventors:

David Wolf - Sudbury MA, US
Claire McGrath - West Boylston MA, US
Willem Kuhtreiber - Shrewsbury MA, US
Jeanine Lorusso - Sterling MA, US
Angela Pollard - Westminster MA, US

International Classification:

A61K009/00
A61K009/48
A61K009/50

US Classification:

424/400000, 424/451000, 424/093700

Abstract:

A method of determining a suitable microreactor for a predetermined host including identifying a suitable microreactor diameter, optionally identifying a minimum second matrix thickness, and optionally identifying a microreactor having a centrally located microcapsule. A microreactor having a diameter such that, when implanted in a higher order mammal, the microreactor exhibits no greater than 25% fibrosis for at least 14 days after implantation. A microreactor that includes a semipermeable membrane capable of eliciting a fibrotic response from a higher order mammal, and a second matrix surrounding the semipermeable membrane, the second matrix being of a thickness sufficient to prevent nucleation of fibrosis by the semipermeable membrane when the microreactor is implanted in a higher order mammal for at least 14 days.