UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA, US Clay Wang - San Marino CA, US
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA
International Classification:
A61K 31/7048 A61K 31/216
US Classification:
514 27, 536 181, 560 75
Abstract:
This invention demonstrates the therapeutic efficacy of Yang-Gan-Wan (YGW) and its active components, especially in the formulation provided by Sheng-Pu Pharmaceutials, Inc., for treating and preventing liver fibrosis. This invention further demonstrates MeCP2 is an important therapeutic target for YGW and its active ingredients' action against liver fibrosis and cirrhosis.
- Lawrence KS, US - Los Angeles CA, US Ruth Entwistle - Lawrence KS, US Christine Oakley - Lawrence KS, US Yi-Ming Chiang - Temple City CA, US Clay Wang - San Marino CA, US
International Classification:
C12N 15/80 C07K 7/06
Abstract:
Modified fungal strains having deleted gene clusters are provided. The modified fungal strains include . The deleted gene clusters are selected from the group of gene clusters responsible for the biosynthesis of sterigmatocystin, emericellamides, asperfuranone, monodictyphenone, terrequinone, F9775A, F9775B, asperthecin, and both portions of the split cluster that makes austinol and dehydroaustinol. Methods for making compounds by culturing the fungus in a growth media and separating the compound from the fungus and/or separating the compound from the growth media are included, as are the compounds and compositions comprising them.
Epigenetic Mechanisms Of Anti-Fibrotic Action For The Liver
- Los Angeles CA, US Clay Wang - San Marino CA, US
Assignee:
University of Southern California - Los Angeles CA
International Classification:
A61K 31/7048
Abstract:
This invention demonstrates the therapeutic efficacy of Yang-Gan-Wan (YGW) and its active components, especially in the formulation provided by Sheng-Pu Pharmaceutials, Inc., for treating and preventing liver fibrosis. This invention further demonstrates MeCP2 is an important therapeutic target for YGW and its active ingredients' action against liver fibrosis and cirrhosis.
Associate Professor at University of Southern California
Location:
Los Angeles, California
Industry:
Research
Work:
University of Southern California - Greater Los Angeles Area since Jul 2003
Associate Professor
Education:
Stanford University 2001 - 2003
Postdoctoral Fellowship, Chemistry, Chemical Engineering
California Institute of Technology 1996 - 2001
Ph.D., Chemistry
Harvard College 1992 - 1996
1996, Chemistry
At the ISS, they will be defrosted and provided a perfect temperature of 98.6 degrees Fahrenheit for growth for a maximum of seven days. The study lead and USC professor Clay Wang and his team will receive the fungi back for further investigations in May 2016. One good and familiar example is penicillin. However, scientists (including USC professor Clay Wang who's leading this project) found that in many cases, fungi can only generate secondary metabolites when they're put in stressful conditions. And space can provide an environment harsh enough to acti
We know that these organisms, when they go to space, theyll be stressed, said Clay Wang, lead researcher and professor of pharmacology and pharmaceutical sciences and chemistry at the University of Southern California. When theyre stressed, something will happen and thats what were interested