Clifford J Unkefer

US Patent:

6541671, Apr 1, 2003

Filed:

Feb 13, 2002

Appl. No.:

10/074669

Inventors:

Rodolfo A. Martinez - Santa Fe NM
Marc A. Alvarez - Santa Fe NM
Clifford J. Unkefer - Los Alamos NM

Assignee:

The Regents of the University of California - Los Alamos NM

International Classification:

C07C32116

US Classification:

568 57, 568 38, 424 165, 424 181

Abstract:

The present invention is directed to labeled compounds, [2- C]dithiane wherein the C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to processes of preparing [2- C]dithiane wherein the C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to labeled compounds, e. g. , [ H , C]methanol (arylthio)-, acetates wherein the C atom is directly bonded to exactly one or two deuterium atoms.

US Patent:

6627396, Sep 30, 2003

Filed:

Oct 27, 2000

Appl. No.:

09/699225

Inventors:

Basil I. Swanson - Los Alamos NM
Xuedong Song - Los Alamos NM
Clifford Unkefer - Los Alamos NM
Jurgen G. Schmidt - Los Alamos NM

Assignee:

The Regents of the University of California - Los Alamos NM

International Classification:

G01N 3353

US Classification:

435 5, 435 71, 435 79, 435 792, 435174, 4352351, 4352871, 4352872, 4352887, 435808, 435817, 436 56, 436128, 436164, 436172, 436518, 436524, 436529, 436805, 436811, 436815, 356 731, 356432, 356445, 356928, 422 57, 422 681, 422 8201, 422 8205, 422 8211

Abstract:

A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.

US Patent:

6709645, Mar 23, 2004

Filed:

Apr 18, 2003

Appl. No.:

10/419310

Inventors:

Rodolfo A. Martinez - Santa Fe NM
Clifford J. Unkefer - Los Alamos NM
Robert Atcher - White Rock NM

Assignee:

The Regents of the University of California - Los Alamos NM

International Classification:

A61K 5104

US Classification:

424 181, 568 27, 568 28, 568 32, 568579, 568606, 568613, 568671

Abstract:

The present invention is directed to labeled compounds, for example, isotopically enriched mustard gas metabolites including: [1,1â,2,2â- C ]ethane, 1,1â-sulfonylbis[2-(methylthio); [1,1â,2,2â- C ]ethane, 1-[[2-(methylsulfinyl)ethyl]sulfonyl]-2-(methylthio); [1,1â,2,2â- C ]ethane, 1,1â-sulfonylbis[2-(methylsulfinyl)]; and, 2,2â-sulfinylbis([1,2- C ]ethanol of the general formula where Q is selected from the group consisting of sulfide (âSâ), sulfone (âS(O)â), sulfoxide (âS(O )â) and oxide (âOâ), at least one C* is C, X is selected from the group consisting of hydrogen and deuterium, and Z is selected from the group consisting of hydroxide (âOH), and âQ âR where Q is selected from the group consisting of sulfide (âSâ), sulfone(âS(O)â), sulfoxide (âS(O )â) and oxide (âOâ), and R is selected from the group consisting of hydrogen, a C to C lower alkyl, and amino acid moieties, with the proviso that when Z is a hydroxide and Q is a sulfide, then at least one X is deuterium.

US Patent:

6713044, Mar 30, 2004

Filed:

Jan 14, 2003

Appl. No.:

10/342577

Inventors:

Rodolfo A. Martinez - Santa Fe NM
Marc A. Alvarez - Santa Fe NM
Clifford J. Unkefer - Los Alamos NM

Assignee:

The Regents of the University of California - Los Alamos NM

International Classification:

A61K 5100

US Classification:

424 181, 568 38

Abstract:

The present invention is directed to labeled compounds, [ H , C], [ H , C] and [ H , C]methyl aryl sulfides wherein the C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure wherein R , R , R , R , and R are each independently, hydrogen, a C -C lower alkyl, a halogen, an amino group from the group consisting of NH , NHR and NRRâ where R and Râ are each a C -C lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing [ H , C], [ H , C] and [ H , C]methyl aryl sulfides wherein the C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms. The present invention is also directed to the labeled compounds of [ H , C]methyl iodide and [ H , C]methyl iodide.

US Patent:

6730805, May 4, 2004

Filed:

Apr 1, 2003

Appl. No.:

10/405683

Inventors:

Rodolfo A. Martinez - Santa Fe NM
Marc A. Alvarez - Santa Fe NM
Clifford J. Unkefer - Los Alamos NM

Assignee:

The Regents of the University of California - Los Alamos NM

International Classification:

C07C 6902

US Classification:

560231, 560129, 424 165, 424 181

Abstract:

The present invention is directed to labeled compounds, [2- C]dithane wherein the C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to processes of preparing [2- C]dithane wherein the C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to labeled compounds, e. g. , [ H , C]methanol (arylthio)-, acetates wherein the C atom is directly bonded to exactly one or two deuterium atoms.

US Patent:

6753446, Jun 22, 2004

Filed:

Jun 5, 2003

Appl. No.:

10/456081

Inventors:

Rodolfo A. Martinez - Santa Fe NM
Clifford J. Unkefer - Los Alamos NM
Marc A. Alvarez - Santa Fe NM

Assignee:

The Regents of the University of California - Los Alamos NM

International Classification:

C07C22900

US Classification:

560155, 560190, 558255

Abstract:

The present invention is directed to labeled compounds, specifically where each C* is selected from the group consisting of a carbon-12, i. e. , C, or a carbon-13, i. e. , C and at least one C* is C, R is selected from the group of C -C lower alkyl and aryl, and X is selected from the group of âNR R where R and R are each independently selected from the group of C -C lower alkyl, alkoxy and aryl, âSR where R is selected from the group of C -C lower alkyl, alkoxy and aryl, and âOR where R is selected from the group of C -C lower alkyl, alkoxy and aryl with the proviso that when R is methyl then R is other than methyl, when R is ethyl then R is other than ethyl, and when R is benzyl then R is other than benzyl.

US Patent:

6764673, Jul 20, 2004

Filed:

Jan 14, 2003

Appl. No.:

10/342521

Inventors:

Rodolfo A. Martinez - Santa Fe NM
Marc A. Alvarez - Santa Fe NM
Clifford J. Unkefer - Los Alamos NM
Jurgen G. Schmidt - Los Alamos NM

Assignee:

The Regents of the University of California - Los Alamos NM

International Classification:

A61K 5100

US Classification:

424 181, 568 27, 568 28

Abstract:

The present invention is directed to labeled compounds, [ H , C], [ H , C] and [ H , C]methyl aryl sulfones and [ H , C], [ H , C] and [ H , C]methyl aryl sulfoxides, wherein the C methyl group attached to the sulfur of the sulfone or sulfoxide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure: wherein R , R , R , R and R are each independently, hydrogen, a C -C lower alkyl, a halogen, an amino group from the group consisting of NH , NHR and NRRâ where R and Râ are each a C -C lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing methyl aryl sulfones and methyl aryl sulfoxides.

US Patent:

6893814, May 17, 2005

Filed:

Aug 28, 2003

Appl. No.:

10/651141

Inventors:

Basil I. Swanson - Los Alamos NM, US
Xuedong Song - Los Alamos NM, US
Clifford Unkefer - Los Alamos NM, US
Jurgen G. Schmidt - Los Alamos NM, US

Assignee:

The Regents of the University of California - Los Alamos NM

International Classification:

G01N033/53
G01N033/543

US Classification:

435 5, 422 57, 422 681, 422 8201, 422 8205, 422 8211, 435 71, 435 79, 435 792, 435174, 4352351, 4352871, 4352872, 4352887, 435808, 435817, 436 56, 436128, 436164, 436172, 436518, 436524, 436529, 436805, 436811, 436815, 356 731, 356432, 356445, 356928

Abstract:

A sensor for the detection of tetrameric multivalent neuraminidase within a sample is disclosed, where a positive detection indicates the presence of a target virus within the sample. Also disclosed is a trifunctional composition of matter including a trifunctional linker moiety with groups bonded thereto including (a) an alkyl chain adapted for attachment to a substrate, (b) a fluorescent moiety capable of generating a fluorescent signal, and (c) a recognition moiety having a spacer group of a defined length thereon, the recognition moiety capable of binding with tetrameric multivalent neuraminidase.