Clinton S Robison

US Patent:

7998704, Aug 16, 2011

Filed:

Mar 14, 2005

Appl. No.:

11/080732

Inventors:

Eric T. Ahrens - Pittsburgh PA, US
Clinton S. Robison - Pittsburgh PA, US

Assignee:

Carnegie Mellon University - Pittsburgh PA

International Classification:

C12P 21/04
C12P 21/06
C12N 15/00
C07H 21/04

US Classification:

435 697, 4353201, 435 696, 435 691, 435 4, 536 234

Abstract:

In certain aspects the present invention provides methods and compositions related to contrast agents for magnetic resonance imaging. In certain variations, contrast agents provided herein are generated in situ via genetic instructions and become potent upon sequestering available metal atoms. Exemplary contrast agents include metal-binding proteins.

US Patent:

20050260601, Nov 24, 2005

Filed:

Sep 8, 2003

Appl. No.:

10/656894

Inventors:

Michael Whitt - Cordova TN, US
Clinton Robison - Pittsburgh PA, US
Himangi Jayakar - Cordova TN, US
Mark Miller - Germantown TN, US

International Classification:

C12Q001/68
G01N033/574

US Classification:

435006000, 435007230

Abstract:

The present invention relates to recombinant Rhabdoviridae, isolated nucleic acids, vectors, cells and compositions comprising same. The recombinant Rhabdoviridae, isolated nucleic acids, vectors, cells and compositions express Rhabdoviral proteins including a mutated matrix protein (M) and/or a mutated glycoprotein (G), in addition to expression of at least one foreign nucleic acid. The present invention also relates to methods of use thereof, including their use in vivo, in anti-cancer applications, such as in the treatment of gliomas. The recombinant Rhabdoviridae of the present invention are also useful in gene therapy and vaccine applications.

US Patent:

20120021450, Jan 26, 2012

Filed:

Jul 18, 2011

Appl. No.:

13/184757

Inventors:

Eric T. Ahrens - Pittsburgh PA, US
Clinton S. Robison - Pittsburgh PA, US

Assignee:

CARNEGIE MELLON UNIVERSITY - Pittsburgh PA

International Classification:

C12Q 1/02
C12N 15/62
C12N 15/867
C12N 15/861
C12N 15/863
C12N 15/869
C07K 19/00
C12N 15/86

US Classification:

435 29, 530400, 536 234, 4353201

Abstract:

In certain aspects the present invention provides methods and compositions related to contrast agents for magnetic resonance imaging. In certain variations, contrast agents provided herein are generated in situ via genetic instructions and become potent upon sequestering available metal atoms. Exemplary contrast agents include metal-binding proteins.