Clive Roy Taylor

US Patent:

6682648, Jan 27, 2004

Filed:

Jun 26, 1998

Appl. No.:

09/105538

Inventors:

Robert D. MacPhee - Los Angeles CA
Clive R. Taylor - Los Angeles CA
Rainer Hintsche - Itzehoe, DE
Rene Seitz - Itzehoe, DE

Assignee:

University of Southern California - Los Angeles CA

International Classification:

G02N 2726

US Classification:

2057775, 204403

Abstract:

An immunochemical and molecular biologic endpoint reporter system in which reaction products, coupled to electrochemically active molecules susceptible to redox recycling or coupled to enzymes capable of proportional generation of said electrochemically active molecules, are detected and/or quantitated using amperiometry in conjunction with a silicon microchip possessing a closely spaced interdigitated array of nobel metal electrodes.

US Patent:

8361738, Jan 29, 2013

Filed:

Mar 4, 2010

Appl. No.:

12/717402

Inventors:

Emil P. Kartalov - Pasadena CA, US
Axel Scherer - Laguna Beach CA, US
Clive Taylor - Malibu CA, US

Assignee:

California Institute of Technology - Pasadena CA
University of Southern California - Los Angeles CA

International Classification:

G01N 33/00

US Classification:

435 794

Abstract:

Described herein is a method for detection of a target in a sample and related devices and systems.

US Patent:

8424560, Apr 23, 2013

Filed:

Dec 11, 2009

Appl. No.:

12/636086

Inventors:

Emil P. Kartalov - Pasadena CA, US
John Liu - Gilbert AZ, US
Axel Scherer - Laguna Beach CA, US
Clive Taylor - Malibu CA, US

Assignee:

University of Southern California - Los Angeles CA
California Institute of Technology - Pasadena CA

International Classification:

F16K 31/365
F16K 31/36
F15C 3/04
F15C 1/06

US Classification:

13750512, 13750513, 137829, 137833

Abstract:

Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in microfluidic devices.

US Patent:

20060263818, Nov 23, 2006

Filed:

May 22, 2006

Appl. No.:

11/439288

Inventors:

Axel Scherer - Laguna Beach CA, US
Emil Kartalov - Los Angeles CA, US
W. Anderson - San Gabriel CA, US
Clive Taylor - South Pasadena CA, US

International Classification:

C12Q 1/68
G01N 33/53
C12M 1/34

US Classification:

435006000, 435007100, 435287200

Abstract:

The development of a high-throughput multi-antigen microfluidic fluorescence immunoassay system is illustrated in a 100-chamber PDMS (polydimethylsiloxane) chip which performs up to 5 tests for each of 10 samples. Specificity of detection is demonstrated and calibration curves produced for C-Reactive Protein (CRP), Prostate Specific Antigen (PSA), ferritin, and Vascular Endothelial Growth Factor (VEGF). The measurements show sensitivity at and below levels that are significant in current clinical laboratory practice (with SIN>8 at as low as 10 pM antigen concentration). The chip uses 100 nL per sample for all four tests and provides an improved instrument for use in scientific research and “point-of-care” testing in medicine.

US Patent:

20080038771, Feb 14, 2008

Filed:

Jun 29, 2007

Appl. No.:

11/772042

Inventors:

Clive Taylor - South Pasadena CA, US
Shan Shi - Los Angeles CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

G01N 33/48
C12Q 1/00

US Classification:

435040500, 435004000

Abstract:

Methods for identifying Quantifiable Internal Reference Standards (QIRS) for immunohistochemistry (IHC). Also disclosed are methods for using QIRS to quantify test antigens in IHC.

US Patent:

20100267162, Oct 21, 2010

Filed:

Apr 15, 2010

Appl. No.:

12/761299

Inventors:

Emil P. KARTALOV - Pasadena CA, US
Axel Scherer - Laguna Beach CA, US
Clive R. Taylor - Malibu CA, US

International Classification:

G01N 27/22
G01N 27/00

US Classification:

436149, 422 8201

Abstract:

Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.

US Patent:

20110177518, Jul 21, 2011

Filed:

Jan 20, 2011

Appl. No.:

13/010761

Inventors:

Emil P. Kartalov - Pasadena CA, US
Darryl Shibata - Rolling Hill Estates CA, US
Clive Taylor - Malibu CA, US
Lawrence A. Wade - La Canada-Flintridge CA, US

International Classification:

C12Q 1/68
C12M 1/00
C12N 13/00
C12Q 1/02
G01N 33/53
G03F 7/20

US Classification:

435 612, 4352831, 4351739, 435 29, 435 71, 435 61, 430320

Abstract:

Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest against DNA-destroying illumination. The micro-isolation apparatus can further comprise photosensitive material defining access wells following illumination and subsequent developing of the photosensitive material. The micro-isolation apparatus can further comprise a chambered microfluidic device comprising channels providing access to wells defined in photosensitive material. The micro-isolation apparatus can comprise a chambered microfluidic device without access wells defined in photosensitive material where valves control the flow of gases or liquids through the channels of the microfluidic device. Also included are methods for selectively isolating cellular material using the apparatuses described herein, as are methods for biochemical analysis of individual regions of interest of cellular material using the devices described herein. Further included are methods of making masking arrays useful for the methods described herein.

US Patent:

20110306064, Dec 15, 2011

Filed:

Jun 30, 2011

Appl. No.:

13/174585

Inventors:

Clive R. Taylor - South Pasadena CA, US
Shan Rong Shi - Los Angeles CA, US

International Classification:

G01N 33/53

US Classification:

435 721, 435 71, 435 792

Abstract:

Methods for identifying Quantifiable Internal Reference Standards (QIRS) for immunohistochemistry (IHC). Also disclosed are methods for using QIRS to quantify test antigens in IHC.