Colin L Smithpeter

US Patent:

6370422, Apr 9, 2002

Filed:

Mar 19, 1999

Appl. No.:

09/272719

Inventors:

Colin L. Smithpeter - Albuquerque NM
Brett S. Bowman - Palo Alto TX
Michael R. Descour - Tucson AZ

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61B 600

US Classification:

600478, 600182, 606 10

Abstract:

An apparatus and methods for fiber optic confocal imaging systems. A plurality of fibers are in communication with a scan system that controllably deflects incident radiation into the fibers in a raster pattern. An index matching agent reduces specular reflections from the fibers.

US Patent:

6593101, Jul 15, 2003

Filed:

Mar 28, 2001

Appl. No.:

09/821843

Inventors:

Rebekah Drezek - Houston TX
Colin Smithpeter - Albuquerque NM
Tom Collier - Austin TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

C12Q 102

US Classification:

435 29, 4352831, 435968, 600478, 424 96

Abstract:

Methods for enhancing contrast during imaging to assess cell and nuclear morphology of a sample. A contrast agent such as acetic acid, toluidine blue, hypertonic saline, hypotonic saline, Lugols iodine, an absorbing dye, a liposome, or a contrast agent linked to a marker are applied to a sample. The sample is analyzed with an imaging device to create image data, and the sample is diagnosed using the image data.

US Patent:

7274815, Sep 25, 2007

Filed:

Oct 9, 2003

Appl. No.:

10/681961

Inventors:

Colin L. Smithpeter - Albuquerque NM, US
Eddie R. Hoover - Sandia Park NM, US
Bedabrata Pain - Los Angeles CA, US
Bruce R. Hancock - Altadena CA, US
Robert O. Nellums - Albuquerque NM, US

Assignee:

Sandia Corporation - Albuquerque NM
California Institute of Technology - Pasadena CA

International Classification:

G06K 9/00

US Classification:

382154

Abstract:

An apparatus is disclosed for generating a three-dimensional (3-D) image of a scene illuminated by a pulsed light source (e. g. a laser or light-emitting diode). The apparatus, referred to as a phase-sensitive 3-D imaging camera utilizes a two-dimensional (2-D) array of photodetectors to receive light that is reflected or scattered from the scene and processes an electrical output signal from each photodetector in the 2-D array in parallel using multiple modulators, each having inputs of the photodetector output signal and a reference signal, with the reference signal provided to each modulator having a different phase delay. The output from each modulator is provided to a computational unit which can be used to generate intensity and range information for use in generating a 3-D image of the scene. The 3-D camera is capable of generating a 3-D image using a single pulse of light, or alternately can be used to generate subsequent 3-D images with each additional pulse of light.

US Patent:

6187289, Feb 13, 2001

Filed:

Oct 20, 1998

Appl. No.:

9/175234

Inventors:

Rebekah Drezek - Austin TX
Colin Smithpeter - Albuquerque NM
Andres F. Zuluaga - Austin TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 4900
A01N 3700

US Classification:

424 98

Abstract:

A method for using acetic acid as a contrast agent during reflectance confocal imaging of normal and neoplastic tissue, particularly epithelium. In one aspect, the invention includes a method of using acetic acid as a contrast agent for confocal imaging of cells, including applying acetic acid to the diagnostic tissue sample in sufficient concentration to induce a small scale alteration of the index of refraction of nuclei in the cells; and imaging such cells using a reflectance confocal imaging system.