Colleen C Brophy

US Patent:

20160058876, Mar 3, 2016

Filed:

Apr 11, 2014

Appl. No.:

14/784017

Inventors:

- Nashville TN, US
Brian Connor Evans - Bartlett TN, US
Colleen Brophy - Nashville TN, US
Kyle Hocking - Alpharetta GA, US

International Classification:

A61K 47/48
A61L 27/54
A61K 31/711
A61L 27/26
A61K 38/00
A61K 31/7105

Abstract:

The present disclosure relates to compounds comprising (i) an active agent, wherein the active agent includes a charge at a predetermined pH, (ii) a polymer, wherein the polymer includes an opposite charge than the active agent at the predetermined pH; and (iii) a polyplex comprising the peptide and the polymer electrostatically bond together at the predetermined pH. In some embodiments, the active agent is a peptide, such as a peptide comprising MAPKAP kinase II inhibitory peptide, and in some embodiments the peptide includes a cell-penetrating peptide. In further embodiments, the disclosure provides methods for treating a disease or condition by administering a composition according to the present disclosure to a subject in need thereof.