Bates College
Assistant Professor of Chemistry and Biochemistry
Stanford University Sep 2017 - Jun 2018
Postdoctoral Scholar
Ucsf Apr 2014 - Aug 2017
Postdoctoral Fellow
Princeton University Jul 2009 - Feb 2014
Graduate Student Researcher
Princeton University Jan 2011 - Feb 2014
Graduate Student Teaching Assistant
Education:
Princeton University 2009 - 2014
Doctorates, Doctor of Philosophy, Molecular Biology, Philosophy
Princeton University 2009 - 2011
Masters, Molecular Biology
Ithaca College 2005 - 2008
Bachelors, Biochemistry
West Nottingham Academy 2005
Skills:
Biochemistry Molecular Biology Genetics Protein Purification Protein Assays Teaching Pcr Rt Pcr Molecular Cloning Scientific Writing Cell Biology Science
A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote from quorum-sensing-mediated killing by the bacterial pathogen . The saving of demonstrates the use of these molecules as small molecule antimicrobials.
Small Molecule Antagonists Of Bacterial Quorum-Sensing Receptors
Bonnie L. Bassler - Princeton NJ, US Lee R. Swem - Lawrenceville NJ, US Scott M. Ulrich - Ithaca NY, US Colleen T. O'Loughlin - Princeton NJ, US
International Classification:
A01N 43/08 A61K 31/365
US Classification:
514472
Abstract:
A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote from quorum-sensing-mediated killing by the bacterial pathogen . The saving of demonstrates the use of these molecules as small molecule antimicrobials.
Small Molecule Antagonists Of Bacterial Quorum-Sensing Receptors
- Princeton NJ, US Lee R. Swem - Montara CA, US Scott M. Ulrich - Ithaca NY, US Colleen T. O'Loughlin - San Francisco CA, US
Assignee:
The Trustees of Princeton University - Princeton NJ
International Classification:
A61K 31/365
Abstract:
A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote from quorum-sensing-mediated killing by the bacterial pathogen . The saving of demonstrates the use of these molecules as small molecule antimicrobials.
Systems And Methods To Detect Biofilm Streamer Growth And Their Uses
- Princeton NJ, US Howard A. Stone - Princeton NJ, US Martin F. Semmelhack - Princeton NJ, US Knut Drescher - Princeton NJ, US Yi Shen - Zurich, CH Colleen T. O'Loughlin - San Francisco CA, US Laura C. Miller - Princeton NJ, US
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY - Princeton NJ
International Classification:
C12Q 1/18 C12Q 1/02
Abstract:
The present invention relates to a method of measuring biofilms and/or biofilm streamers, wherein the method comprises a system that has at least one channel and a biofilm streamer promotion element, a fluid capable of moving along the channel, wherein the fluid has a flow driven by a controlled pressure; and a measuring element capable of measuring a flow rate of the fluid through the channel. Additionally, method of screening for compound(s) that promote and/or inhibit biofilm and/or biofilm streamers using this system are also contemplated. Uses of the system, methods and identified compounds are contemplated for medical and/or industrial environments.
Small Molecule Antagonists Of Bacterial Quorum-Sensing Receptors
Bonnie L. Bassler - Princeton NJ, US Lee R. Swem - Montara CA, US Scott M. Ulrich - Ithaca NY, US Colleen T. O'Loughlin - Princeton NJ, US
Assignee:
THE TRUSTEES OF PRINCETON UNIVERSITY - Princeton NJ
International Classification:
A01N 43/10 A01N 43/08
US Classification:
514445, 549321, 549 63
Abstract:
A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote from quorum-sensing-mediated killing by the bacterial pathogen . The saving of demonstrates the use of these molecules as small molecule antimicrobials.
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Colleen O'loughlin
Youtube
Colleen O'Loughlin Rainbow Memorial Video
Watch Colleen O'Loughlin of UCSF talk about the bacteria that lives in...
Duration:
6m 31s
Colleen O'Loughlin (Fischbach's Lab)
Duration:
1m 21s
1st video...still an amateur!
Duration:
7m 5s
Coming in from deck
I created this video with the YouTube Video Editor ( )
Duration:
31s
The sad life of Alex O'Loughlin
The sad life of Alex O'Loughlin Alex O'Loughlin was born on 24 August ...
Duration:
5m 25s
Coming up from basement
I created this video with the YouTube Video Editor ( )