Constance E Brinckerhoff from 23 Rivermead Rd, Peterborough, NH 03458, age 82, Phone: 6035262527

Kit For Diagnosing And Prognosticating Matrix Metalloproteinase-1 Related Disease Via A Matrix Metalloproteinase-1 Single Nucleotide Polymorphism
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US Patent:

7473774, Jan 6, 2009
Filed:

Apr 20, 2006
Appl. No.:

11/408202
Inventors:

Constance E. Brinckerhoff - Norwich VT, US
Joni L. Rutter - Silverspring MD, US
Assignee:

Trustees of Dartmouth College - Hanover NH
International Classification:

C07H 21/04
C12Q 1/68
US Classification:

536 243, 536 231, 435 6, 435 911, 435 912
Abstract:

Methods and kits for diagnosing and prognosticating matrix metalloproteinase-1 related disease by detecting a single nucleotide polymorphism in the promoter of the gene are provided. Also provided are methods of identifying agents which inhibit binding of transcriptions factors to the Ets transcription factor binding site created by or resulting from this single nucleotide polymorphism and methods of using these agents to treat matrix metalloproteinase-1 related diseases.

Compositions And Methods For Inhibiting The Synthesis Or Expression Of Mmp-1
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US Patent:

7511025, Mar 31, 2009
Filed:

Jun 10, 2005
Appl. No.:

11/628829
Inventors:

Colby Wyatt - West Lebanon NH, US
Constance F. Brinckerhoff - New London NH, US
Assignee:

Trustees of Dartmouth College - Hanover NH
International Classification:

A61K 31/70
C07H 21/04
US Classification:

514 44, 536 231, 536 245
Abstract:

The present invention relates to the specific inhibition of matrix metalloproteinase 1 (MMP-1) using agents which inhibit the synthesis or expression of MMP-1. Such agents are useful for suppressing invasion or metastasis of a tumor cell and in the treatment, prevention and management of cancer.

Compositions And Methods For Inhibiting The Synthesis Or Expression Of Mmp-1
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US Patent:

7790697, Sep 7, 2010
Filed:

Jan 12, 2009
Appl. No.:

12/352214
Inventors:

Colby Wyatt - West Lebanon NH, US
Constance F. Brinckerhoff - New London NH, US
Assignee:

Trustees of Dartmouth College - Hanover NH
International Classification:

A61K 31/70
C07H 21/04
US Classification:

514 44, 536 231, 536 345
Abstract:

The present invention relates to the specific inhibition of matrix metalloproteinase 1 (MMP-1) using agents which inhibit the synthesis or expression of MMP-1. Such agents are useful for suppressing invasion or metastasis of a tumor cell and in the treatment, prevention and management of cancer.

Compositions And Methods For Preventing Joint Destruction In Osteoarthritis
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US Patent:

20130035357, Feb 7, 2013
Filed:

Apr 13, 2011
Appl. No.:

13/641173
Inventors:

Richard Chou - West Lebanon NH, US
Constance E. Brinckerhoff - New London NH, US
Daniel A. Albert - Etna NH, US
Assignee:

TRUSTEES OF DARTMOUTH COLLEGE - Hanover NH
International Classification:

A61K 31/192
A61P 29/00
A61K 31/4706
A61P 19/02
US Classification:

514313, 514569
Abstract:

The present invention is methods for inhibiting collagen destruction in joints of osteoarthritis patients. The methods are based on use of rexinoid compounds, in particular bexarotene, and their activity to inhibit synthesis of matrix metalloproteinases (MMPs) in affected tissue.

Methods Of Diagnosing, Prognosticating And Treating Matrix Metalloproteinase-1 Related Diseases Via A Matrix Metalloproteinase-1 Single Nucleotide Polymorphism
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US Patent:

7033756, Apr 25, 2006
Filed:

Nov 10, 1999
Appl. No.:

09/856749
Inventors:

Constance E. Brinckerhoff - Norwich VT, US
Joni L. Rutter - Silverspring MD, US
Assignee:

Trustees of Dartmouth College - Hanover NH
International Classification:

C07H 21/04
C12Q 1/68
US Classification:

435 6, 536 231
Abstract:

Methods and kits for diagnosing and prognosticating matrix metalloproteinase-1 related disease by detecting a single nucleotide polymorphism in the promoter of the gene are provided. Also provided are methods of identifying agents which inhibit binding of transcriptions factors to the Ets transcription factor binding site created by or resulting from this single nucleotide polymorphism and methods of using these agents to treat matrix metalloproteinase-1 related diseases.

Constance E Brinckerhoff