Constance Shanel Johnson

US Patent:

6821784, Nov 23, 2004

Filed:

Nov 16, 2001

Appl. No.:

09/979049

Inventors:

Tedros Bezabeh - Winnipeg, CA
Ian C. P. Smith - Winnipeg, CA
Charles Noah Bernstein - Winnipeg, CA
Bernard Levin - Houston TX
Constance Johnson - Bellaire TX

Assignee:

The University of Manitoba - Winnipeg
National Research Council of Canada - Ottawa
Board of Regents, University of Texas System - Austin TX

International Classification:

G01N 3348

US Classification:

436 64, 435 4, 435 723, 324300, 436 63, 436 91, 436 93, 436 94, 436173, 436179

Abstract:

Two dimensional COSY magnetic resonance spectroscopy of human stool can be used in a non-invasive method of detecting the presence of colorectal cancer. The spectrum of a patients stool is compared with that of stool from non-cancerous subjects, observed differences in spectra being indicative of cancer.

US Patent:

20030148260, Aug 7, 2003

Filed:

Feb 6, 2003

Appl. No.:

10/359088

Inventors:

Bernard Levin - Houston TX, US
Ian Smith - Winnipeg, CA
Rajmund Somoraji - Headingley, CA
Constance Johnson - Bellaire TX, US
Tedros Bezabeh - Winnipeg, CA
Charles Bernstein - Winnipeg, CA

International Classification:

C12Q001/00
G01N033/574

US Classification:

435/004000, 435/007230

Abstract:

One dimensional proton magnetic resonance spectroscopy of human stool can be used as non-invasive method of detecting the presence of colorectal cancer and/or clinically significant adenomas. The spectrum of a patient's stool is compared with that of stool from non-cancerous subjects, observed differences in spectra being indicative of cancer and/or clinically significant adenomas. In a preferred method, the stool sample is mixed with a buffer, the resulting suspension is centrifuged and the supernatant is subjected to magnetic resonance spectroscopy.