Corinne S Lengsfeld

US Patent:

6403672, Jun 11, 2002

Filed:

Nov 30, 1999

Appl. No.:

09/451481

Inventors:

Theodore Randolph - Niwot CO
Kristi Anseth - Boulder CO
Jennifer L. Owens - Boulder CO
Corinne Lengsfeld - Denver CO

Assignee:

University Technology Corporation - Boulder CO

International Classification:

C08F 246

US Classification:

522 79, 522 80, 522 87, 522 88, 522 89, 522182, 424486, 424489

Abstract:

Methods of forming polymer particles in situ from polymer precursors such as monomers or oligomers, comprising exposing a composition comprising at least one polymer precursor, a solvent or solvent mixture, and an antisolvent or antisolvent mixture to photoradiation under conditions whereby particles are formed are provided. The polymer precursor may be photosensitive, or a separate polymerization initiator may be used. In a preferred embodiment, the polymer precursor is insoluble in the antisolvent or antisolvent mixture and the solvent or solvent mixture is soluble in the antisolvent or antisolvent mixture at the concentrations used. Polymer particles comprising a polymer and a bioactive material are also provided. The polymer may be erodable, and the polymer particles formed may be used in a variety of applications, including controlled release of bioactive materials such as drugs. Polymer particles formed using the methods of the invention have low residual solvent levels and high additive encapsulation efficiencies.

US Patent:

6864301, Mar 8, 2005

Filed:

Jun 3, 2002

Appl. No.:

10/161544

Inventors:

Theodore Randolph - Niwot CO, US
Kristi Anseth - Boulder CO, US
Jennifer L. Owens - Boulder CO, US
Corinne Lengsfeld - Denver CO, US

Assignee:

The Regents of the University of Colorado - Boulder CO

International Classification:

C08J003/28
C08J009/00
C08K005/00

US Classification:

522 74, 522 75, 522 78, 522 79, 522 80, 522 82, 521 505, 524104, 524205, 524280, 524361, 524379

Abstract:

Methods of forming crosslinked polymer particles in situ from polymer precursors such as monomers or oligomers, comprising exposing a composition comprising at least one polymer precursor, a solvent or solvent mixture, and an antisolvent or antisolvent mixture to photoradiation under conditions whereby particles are formed are provided. The polymer precursor may be photosensitive, or a separate polymerization initiator may be used. In a preferred embodiment, the polymer precursor is insoluble in the antisolvent or antisolvent mixture and the solvent or solvent mixture is soluble in the antisolvent or antisolvent mixture at the concentrations used. Crosslinked polymer particles and crosslinked polymer particles comprising a polymer and a bioactive material are also provided. The polymer may be erodable, and the polymer particles formed may be used in a variety of applications, including controlled release of bioactive materials such as drugs. Polymer particles formed using the methods of the invention have low residual solvent levels and high additive encapsulation efficiencies.

US Patent:

7332111, Feb 19, 2008

Filed:

Jul 10, 2002

Appl. No.:

10/483194

Inventors:

Willy Grothe - Boulder CO, US
Daniel Jarmer - Boulder CO, US
Corinne Lengsfeld - Denver CO, US
Theodore Randolph - Niwot CO, US

Assignee:

The Regents of the University of Colorado - Boulder CO

International Classification:

B29B 9/00

US Classification:

264 11, 264 5, 264 13, 264 14, 425 6

Abstract:

The present invention provides methods and devices for producing particles with an average diameter less than about 15 μm using the precipitation with compressed fluid-antisolvent (PCA) process and the carbon-dioxide assisted nebulization with a bubble dryer (CAN-BD) process. In the methods and nozzles of the invention, at least one jet of supercritical or near-supercritical fluid and at least one jet of solution interact to mix the supercritical or near-supercritical fluid and the solution within a chamber. The solution contains at least one solvent and at least one solute. At least one of the jets is a swirling jet. To form particles, the solvent and supercritical or near-supercritical fluid are then injected into a PCA or a CAN-BD process chamber. The degree of mixing depends in part on the power input into the mixing chamber. Power inputs of about 6.

US Patent:

7914714, Mar 29, 2011

Filed:

May 14, 2004

Appl. No.:

10/555432

Inventors:

Thomas J. Anchordoquy - Lakewood CO, US
Corinne Lengsfeld - Denver CO, US
Kelly Brinkley - Ellicott City MD, US
Ryan Jones - Colorado Springs CO, US

Assignee:

The Regents of the University of Colorado - Denver CO

International Classification:

B01J 13/02

US Classification:

264 41, 4284022, 42840221, 42840224

Abstract:

The methods of the invention employ electrostatic atomization to form a compound droplet of at least two miscible fluids. The compound droplet comprises a core of a first fluid and a layer of a second fluid completely surrounding the core. The first fluid contains the agent to be encapsulated and the second fluid contains an encapsulating agent. The first and second liquids are miscible. The encapsulated droplets can contain a variety of materials including, but not limited to, polynucleotides such as DNA and RNA, proteins, bioactive agents or drugs, food, pesticides, herbicides, fragrances, antifoulants, dyes, oils, inks, cosmetics, catalysts, detergents, curing agents, flavors, fuels, metals, paints, photographic agents, biocides, pigments, plasticizers, propellants and the like and components thereof. The droplets can be encapsulated by a variety of materials, including, but not limited to, lipid bilayers and polymer shells. An additional complete or partial layer of a third fluid can be formed on the outside of the second fluid layer.

US Patent:

20050192371, Sep 1, 2005

Filed:

Mar 2, 2005

Appl. No.:

11/070506

Inventors:

Theodore Randolph - Niwot CO, US
Kristi Anseth - Boulder CO, US
Jennifer Owens - Boulder CO, US
Corinne Lengsfeld - Denver CO, US

International Classification:

C08K003/00

US Classification:

522079000

Abstract:

Methods of forming crosslinked polymer particles in situ from polymer precursors such as monomers or oligomers, comprising exposing a composition comprising at least one polymer precursor, a solvent or solvent mixture, and an antisolvent or antisolvent mixture to photoradiation under conditions whereby particles are formed are provided. The polymer precursor may be photosensitive, or a separate polymerization initiator may be used. In a preferred embodiment, the polymer precursor is insoluble in the antisolvent or antisolvent mixture and the solvent or solvent mixture is soluble in the antisolvent or antisolvent mixture at the concentrations used. Crosslinked polymer particles and crosslinked polymer particles comprising a polymer and a bioactive material are also provided. The polymer may be erodable, and the polymer particles formed may be used in a variety of applications, including controlled release of bioactive materials such as drugs. Polymer particles formed using the methods of the invention have low residual solvent levels and high additive encapsulation efficiencies. The processes of the invention allow control of particle size and morphology, use low operating temperatures and are useful for efficient bulk production.

US Patent:

20060078573, Apr 13, 2006

Filed:

Jun 13, 2005

Appl. No.:

11/152041

Inventors:

Theodore Randolph - Niwot CO, US
Corinne Lengsfeld - Denver CO, US
Daniel Jarmer - Westfield NJ, US

International Classification:

A61K 9/00

US Classification:

424400000

Abstract:

The invention provides methods of modifying the crystal habit of a compound without altering the crystal structure of the compound through a controlled precipitation technique in the presence of a crystal growth inhibitor as well as the crystallized compounds formed by these methods. Using these methods, the crystal habit of the compound may be modified from acicular to bipyramidal. The modification in crystal habit is attributable to a preferential adsorption mechanism of the crystal growth inhibitor to a fast growing crystal face of the compound. Powder flow properties of the crystallized product are significantly enhanced with the habit modification. This selective crystal habit modification using a crystal growth inhibitor provides a strategy to circumvent the manufacturing difficulties associated with acicular crystal habits, and may increase the manufacturing capability of supercritical fluid based crystallization and precipitation technologies.

US Patent:

20080108913, May 8, 2008

Filed:

Nov 6, 2006

Appl. No.:

11/556858

Inventors:

Corinne S. Lengsfeld - Denver CO, US
Rahmat A. Shoureshi - Golden CO, US

Assignee:

Colorado Seminary, which owns and operates The University of Denver - Denver CO

International Classification:

A61B 5/103

US Classification:

600595

Abstract:

Provided is a system for monitoring gait. More particularly, the system comprises: one or more pressure sensors; an algorithm which compares the data from the pressure sensor(s) to a stability profile, and provides a feedback value; means for communicating the feedback value; and a power source. Also provided is a method for gait analysis comprising: collecting signals from one or more pressure sensors located in pressure proximity to a foot, generating a test profile; comparing the test profile to a stability profile; generating a feedback signal; and communicating the feedback signal. The system may also comprise one or more accelerometers.

US Patent:

20090216156, Aug 27, 2009

Filed:

May 5, 2009

Appl. No.:

12/435529

Inventors:

Corinne S. Lengsfeld - Denver CO, US
Rahmat A. Shoureshi - Golden CO, US

Assignee:

Colorado Seminary, which owns and operates The University of Denver - Denver CO

International Classification:

A61B 5/103

US Classification:

600595

Abstract:

Provided is a system for monitoring gait. More particularly, the system comprises: one or more pressure sensors; an algorithm which compares the data from the pressure sensor(s) to a stability profile, and provides a feedback value; means for communicating the feedback value; and a power source. Also provided is a method for gait analysis comprising: collecting signals from one or more pressure sensors located in pressure proximity to a foot, generating a test profile; comparing the test profile to a stability profile; generating a feedback signal; and communicating the feedback signal. The system may also comprise one or more accelerometers.