Novartis Institutes For Biomedical Research (Nibr)
Senior Investigator
Broad Institute Oct 2008 - Nov 2015
Instructor
Broad Institute Oct 2008 - Nov 2015
Senior Group Leader, Drug Resistance and Combinations
Dana-Farber Cancer Institute Oct 2008 - May 2014
Postdoctoral Associate
Harvard Medical School Sep 2003 - Sep 2008
Graduate Student
Education:
Harvard University 2003 - 2008
Doctorates, Doctor of Philosophy, Genetics, Biology
Wheaton College Massachusetts 1997 - 2001
Bachelors, Bachelor of Arts, Biology
Skills:
Molecular Biology Molecular Cloning Cell Biology Cancer Research Western Blotting Cell Culture Genomics Biochemistry Cell Pcr Qpcr Immunohistochemistry Protein Expression Lifesciences Animal Models
Us Patents
Methods Of Diagnosing And Treating Cancer In Patients Having Or Developing Resistance To A First Cancer Therapy
A method of identifying a subject having cancer who is likely to benefit from treatment with a combination therapy with a RAF inhibitor and a second inhibitor is provided. A method of treating cancer in a subject in need thereof is also provided and includes administering to the subject an effective amount of a RAF inhibitor and an effective amount of a second inhibitor, wherein the second inhibitor is a MEK inhibitor, a CRAF inhibitor, a CrkL inhibitor or a TPL2/COT inhibitor. A method of identifying a kinase target that confers resistance to a first inhibitor is also provided.
Methods And Compositions For Studying Cell Evolution
- Cambridge MA, US - Boston MA, US David Feldman - Cambridge MA, US Cory Johannessen - Cambridge MA, US
International Classification:
A61F 13/551 A41D 19/00 C12N 15/10 C12N 15/113
Abstract:
The subject matter disclosed herein is generally directed to methods and compositions for tagging cells of interest, tracking evolution of the tagged cells, and recovering the original tagged cells for further study. Specifically, cells are tagged with a DNA construct encoding a barcode sequence comprising a guide sequence. Barcoded cells can then be recovered using a reporter construct having CRISPR target sequences specific for the cell having a barcode of interest.
Synergistic Drug Combinations Predicted From Genomic Features And Single-Agent Response Profiles
The present disclosure relates to discovery of specific synergistic drug combinations and mechanisms of drug resistance. Compositions involving newly-identified drug combinations as well as diagnostic and therapeutic methods related to such discoveries are provided.
Methods Of Diagnosing And Treating Cancer In Patients Having Or Developing Resistance To A First Cancer Therapy
Levi A. Garraway - Newton MA, US Cory M. Johannessen - Roslindale MA, US
International Classification:
C12Q 1/68 A61K 31/4184 C12N 9/12
Abstract:
A method of identifying a subject having cancer who is likely to benefit from treatment with a combination therapy with a RAF inhibitor and a second inhibitor is provided. A method of treating cancer in a subject in need thereof is also provided and includes administering to the subject an effective amount of a RAF inhibitor and an effective amount of a second inhibitor, wherein the second inhibitor is a MEK inhibitor, a CRAF inhibitor, a CrkL inhibitor or a TPL2/COT inhibitor. A method of identifying a kinase target that confers resistance to a first inhibitor is also provided.