Cory R Nelson

US Patent:

8507287, Aug 13, 2013

Filed:

Sep 11, 2009

Appl. No.:

12/557906

Inventors:

Song Jin - Madison WI, US
Ying Ge - Madison WI, US
Cory Alexander Nelson - Madison WI, US
Qingge Xu - Madison WI, US

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

G01N 33/00

US Classification:

436 86, 436161

Abstract:

The present invention provides methods and materials for isolating, purifying, and/or enriching the concentration of compounds having one or more phosphate groups and/or derivatives thereof, including but not limited to phosphorylated peptides and/or phosphorylated proteins. In some aspects, the present invention provides nanostructured enrichment materials, such as metal oxide mesoporous materials, that selectively and reversibly bind with phosphorylated compounds with high specificity and are capable of controlled release of phosphorylated compounds bound to their active surfaces. Mesoporous materials of the present invention also provide enrichment materials having large active surface areas that provide for higher loading capacities for phosphorylated peptides and proteins relative to conventional affinity based methods. Nanostructured metal oxide mesoporous enrichment materials of the present invention are also compatible with implementation via a variety of separation platforms including flow through separation systems, elution based separation systems, column chromatography and affinity chromatography.

US Patent:

55061893, Apr 9, 1996

Filed:

May 12, 1995

Appl. No.:

8/436948

Inventors:

Hsin-hsin Chou - Woodbury MN
Christopher E. Kunze - Blaine MN
Cory M. Nelson - Falcon Heights MN

Assignee:

Minnesota Mining and Manufacturing Company - St. Paul MN

International Classification:

B41M 5035
B41M 538

US Classification:

503227

Abstract:

A thermal mass transfer imaging process comprises the thermal mass transfer of a dye-receptive transparent donor layer which is then at least partially over-coated with a thermally transferred dye image.