Craig A Thompson

US Patent:

6352694, Mar 5, 2002

Filed:

Mar 10, 1995

Appl. No.:

08/403253

Inventors:

Carl H. June - Rockville MD
Craig B. Thompson - Chicago IL
Gary J. Nabel - Ann Arbor MI
Gary S. Gray - Brookline MA
Paul D. Rennert - Holliston MA

Assignee:

Genetics Institute, Inc. - Cambridge MA
The Regents of the University of Michigan - Ann Arbor MI

International Classification:

A61K 3514

US Classification:

424 9371, 424 937, 424534, 424577, 424578, 435 2, 435375, 435377

Abstract:

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

US Patent:

6395510, May 28, 2002

Filed:

Mar 17, 1999

Appl. No.:

09/271014

Inventors:

Craig B. Thompson - Chicago IL
Lawrence H. Boise - Chicago IL

Assignee:

ARCH Development Corporation - Chicago IL
Board of Regents of The University of Michigan - Ann Arbor MI

International Classification:

C07K 14435

US Classification:

435 691, 530358, 530350

Abstract:

The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

US Patent:

6511828, Jan 28, 2003

Filed:

May 31, 1996

Appl. No.:

08/657759

Inventors:

Craig B. Thompson - Chicago IL
Colin S. Duckett - Chicago IL

Assignee:

Arch Development Corporation - Chicago IL

International Classification:

C12N 1500

US Classification:

435 692, 435 691, 4353201, 435325, 4352523, 536 231, 536 235

Abstract:

A new family of proteins having structural similarity to the baculovirus inhibitor of apoptosis protein (iap) are described. These ilps (iap-like proteins) are distinguished by the presence of a RING finger domain and three baculovirus iap-like repeat motifs. Exemplified are sequences from Drosophila and human. Methods for the use of these proteins, and nucleic acids coding therefor, are provided. These methods include both the inhibition and stimulation of apoptosis in target cells.

US Patent:

6534055, Mar 18, 2003

Filed:

May 4, 1995

Appl. No.:

08/435816

Inventors:

Carl H. June - Rockville MD
Craig B. Thompson - Chicago IL
Gary J. Nabel - Ann Arbor MI
Gary S. Gray - Brookline MA
Paul D. Rennert - Holliston MA

Assignee:

Genetics Institute, Inc. - Cambridge MA

International Classification:

A61K 3514

US Classification:

424 9371, 424 937, 424534, 424577, 424578, 435 2, 435375, 435377

Abstract:

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

US Patent:

6692964, Feb 17, 2004

Filed:

Jun 7, 1995

Appl. No.:

08/475136

Inventors:

Carl H. June - Rockville MD
Craig B. Thompson - Chicago IL
Suil Kim - Ann Arbor MI

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC
The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C12N 1563

US Classification:

435455, 4353201, 424 9321

Abstract:

A method for transfecting T cells with a nucleic acid molecule comprising a gene such that the gene is expressed in the T cells is described. The T cells are stimulated and proliferating prior to introduction of the nucleic acid molecule.

US Patent:

6887466, May 3, 2005

Filed:

Jul 8, 1999

Appl. No.:

09/350202

Inventors:

Carl H. June - Rockville MD, US
Craig B. Thompson - Chicago IL, US
Gary J. Nabel - Ann Arbor MI, US
Gary S. Gray - Brookline MA, US
Paul D. Rennert - Holliston MA, US

Assignee:

Genetics Institute, Inc. - Cambridge MA
Regents of the University of Michigan - Ann Arbor MI
The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61K035/14
A61K035/26
A61K035/28

US Classification:

424 9371, 4241301, 4241411, 4241431, 4241441, 4241531, 4241541, 4241731, 424 937, 424534, 424577, 424578, 435 2, 435 71, 435 721, 435 724, 435375, 435377, 5303871, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875

Abstract:

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

US Patent:

6905680, Jun 14, 2005

Filed:

Jan 26, 1996

Appl. No.:

08/592711

Inventors:

Carl H. June - Rockville MD, US
Craig B. Thompson - Chicago IL, US
Gary J. Nabel - Ann Arbor MI, US
Gary S. Gray - Brookline MA, US
Paul D. Rennert - Holliston MA, US

Assignee:

Genetics Institute, Inc. - Cambridge MA
Regents of the University of Michigan - Ann Arbor MI
The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61K035/14
A61K035/26
A61K035/28

US Classification:

424 9371, 4241301, 4241411, 4241431, 4241441, 4241531, 4241541, 4241731, 424 937, 424534, 424577, 424578, 435 2, 435 71, 435 721, 435 724, 435375, 435377, 5303871, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875

Abstract:

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.

US Patent:

6905681, Jun 14, 2005

Filed:

Jul 8, 1999

Appl. No.:

09/349915

Inventors:

Carl H. June - Rockville MD, US
Craig B. Thompson - Chicago IL, US
Gary J. Nabel - Ann Arbor MI, US
Gary S. Gray - Brookline MA, US
Paul D. Rennert - Holliston MA, US

Assignee:

Genetics Institute, Inc. - Cambridge MA
Regents of the University of Michigan - Ann Arbor MI
The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

A61K035/14
A61K035/26
A61K035/28

US Classification:

424 9371, 4241301, 4241411, 4241431, 4241441, 4241531, 4241541, 4241731, 424 937, 424534, 424577, 424578, 435 2, 435 71, 435 721, 435 724, 435375, 435377, 5303871, 5303881, 5303882, 53038822, 5303887, 53038873, 53038875

Abstract:

Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.